Cellosaurus cell line MOLM-14 (CVCL

Cellosaurus MOLM-14 (CVCL_7916)

[Text version]

Cell line name

MOLM-14

Synonyms

Molm-14; Molm 14; Molm14; MOLM14

Accession

CVCL_7916

Resource Identification Initiative

To cite this cell line use: MOLM-14 (RRID:CVCL_7916)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: 3-4 days (PubMed=9305600); ~50 hours (DSMZ=ACC-777).
Omics: Genomics; ChIP-seq; H3K79me1.
Omics: Proteomics; PTM; Phosphorylation; Quantitative.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Sequence variations

Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (PubMed=9305600).
Mutation; HGNC; HGNC:3765; FLT3; Unexplicit; Internal tandem duplication (FLT3-ITD); ClinVar=VCV000016270; Zygosity=Unspecified (PubMed=12529668).

Disease

Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_2119 ! MOLM-13

Sex of cell

Male

Age at sampling

20Y

Category

Cancer cell line

STR profile

Source(s): COG; DepMap=ACH-001574; DSMZ=ACC-777; JCRB=JCRB1812

Markers:

Amelogenin	X,Y
CSF1PO	10,12
D2S1338	23,25
D3S1358	15
D5S818	10,11
D7S820	10,12
D8S1179	13,14
D13S317	10,11
D16S539	10,11
D18S51	13,15
D19S433	12,14
D21S11	30,31
FGA	21,23
Penta D	9,12
Penta E	18,19
TH01	7
TPOX	8
vWA	16,17

Publications

PubMed=9305600; DOI=10.1038/sj.leu.2400768
Matsuo Y., MacLeod R.A.F., Uphoff C.C., Drexler H.G., Nishizaki C., Katayama Y., Kimura G., Fujii N., Omoto E., Harada M., Orita K.
Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23).
Leukemia 11:1469-1477(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12529668; DOI=10.1038/sj.leu.2402740
Quentmeier H., Reinhardt J., Zaborski M., Drexler H.G.
FLT3 mutations in acute myeloid leukemia cell lines.
Leukemia 17:120-124(2003)

PubMed=21552520; DOI=10.1371/journal.pone.0019169; PMCID=PMC3084268
Gu T.-L., Nardone J., Wang Y., Loriaux M., Villen J., Beausoleil S.A., Tucker M., Kornhauser J.M., Ren J.-M., MacNeill J., Gygi S.P., Druker B.J., Heinrich M.C., Rush J., Polakiewicz R.D.
Survey of activated FLT3 signaling in leukemia.
PLoS ONE 6:e19169.1-e19169.10(2011)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-777
JCRB; JCRB1812

Cell line databases/resources

Cell_Model_Passport; SIDM00436
DepMap; ACH-001574
DSMZCellDive; ACC-777
Lonza; 978

Anatomy/cell type resources

BTO; BTO_0005720

Chemistry resources

ChEMBL-Cells; CHEMBL3706571
ChEMBL-Targets; CHEMBL3706570
PubChem_Cell_line; CVCL_7916

Encyclopedic resources

Wikidata; Q54906323

Experimental variables resources

EFO; EFO_0022446

Gene expression databases

GEO; GSM2037134
GEO; GSM2037135
GEO; GSM3145724

Polymorphism and mutation databases

Cosmic; 787418
Cosmic; 1150898
Cosmic; 1281333

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number