Cellosaurus logo
expasy logo

Cellosaurus MOLM-14 (CVCL_7916)

[Text version]
Cell line name MOLM-14
Synonyms Molm-14; Molm 14; Molm14; MOLM14
Accession CVCL_7916
Resource Identification Initiative To cite this cell line use: MOLM-14 (RRID:CVCL_7916)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: 3-4 days (PubMed=9305600); ~50 hours (DSMZ=ACC-777).
Omics: Deep quantitative phosphoproteome analysis.
Omics: H3K79me1 ChIP-seq epigenome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations
  • Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (PubMed=9305600).
  • Mutation; HGNC; 3765; FLT3; Unexplicit; Internal tandem duplication (FLT3-ITD); ClinVar=VCV000016270; Zygosity=Unspecified (PubMed=12529668).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2119 ! MOLM-13
Sex of cell Male
Age at sampling 20Y
Category Cancer cell line
STR profile Source(s): COG; DepMap; DSMZ; JCRB

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133823,25
D3S135815
D5S81810,11
D7S82010,12
D8S117913,14
D13S31710,11
D16S53910,11
D18S5113,15
D19S43312,14
D21S1130,31
FGA21,23
Penta D9,12
Penta E18,19
TH017
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=9305600; DOI=10.1038/sj.leu.2400768
Matsuo Y., MacLeod R.A.F., Uphoff C.C., Drexler H.G., Nishizaki C., Katayama Y., Kimura G., Fujii N., Omoto E., Harada M., Orita K.
Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23).
Leukemia 11:1469-1477(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12529668; DOI=10.1038/sj.leu.2402740
Quentmeier H., Reinhardt J., Zaborski M., Drexler H.G.
FLT3 mutations in acute myeloid leukemia cell lines.
Leukemia 17:120-124(2003)

PubMed=21552520; DOI=10.1371/journal.pone.0019169
Gu T.-L., Nardone J., Wang Y., Loriaux M., Villen J., Beausoleil S.A., Tucker M., Kornhauser J.M., Ren J., MacNeill J., Gygi S.P., Druker B.J., Heinrich M.C., Rush J., Polakiewicz R.D.
Survey of activated FLT3 signaling in leukemia.
PLoS ONE 6:E19169-E19169(2011)

Cross-references
Cell line collections DSMZ; ACC-777
JCRB; JCRB1812
Cell line databases/resources Cell_Model_Passport; SIDM00436
DepMap; ACH-001574
DSMZCellDive; ACC-777
Lonza; 978
Anatomy/cell type resources BTO; BTO:0005720
Chemistry resources ChEMBL-Cells; CHEMBL3706571
ChEMBL-Targets; CHEMBL3706570
PubChem_Cell_line; CVCL_7916
Encyclopedic resources Wikidata; Q54906323
Gene expression databases GEO; GSM2037134
GEO; GSM2037135
GEO; GSM3145724
Polymorphism and mutation databases Cosmic; 787418
Cosmic; 1150898
Cosmic; 1281333
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number23