Cellosaurus logo
expasy logo

Cellosaurus UM-SCC-5 (CVCL_7762)

[Text version]
Cell line name UM-SCC-5
Synonyms UMSCC-5; UM-SCC5; UMSCC5; University of Michigan-Squamous Cell Carcinoma-5
Accession CVCL_7762
Resource Identification Initiative To cite this cell line use: UM-SCC-5 (RRID:CVCL_7762)
Comments Part of: MD Anderson Cell Lines Project.
Omics: Proteomics; Expression; Reverse-phase protein array.
Derived from site: In situ; Larynx, supraglottis; UBERON=UBERON_0036263.
Sequence variations
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A5TN (UM-SCC-5PT)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): PubMed=19760794

Markers:
AmelogeninX
D3S135817
D5S81813
D7S8209
D8S117911,13
D13S3178,11
D18S5112,16
D21S1131
FGA25
vWA18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=3855324; DOI=10.1288/00005537-198501000-00012
Shan R. Baker;
An in vivo model for squamous cell carcinoma of the head and neck.
Laryngoscope 95:43-56(1985)

PubMed=1851275; DOI=10.1177/019459989110400304
Carol R. Bradford, Susan E. Zacks, Elliot J. Androphy, Lucie Gregoire, Wayne D. Lancaster, Thomas E. Carey;
Human papillomavirus DNA sequences in cell lines derived from head and neck squamous cell carcinomas.
Otolaryngol. Head Neck Surg. 104:303-310(1991)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=12884349; DOI=10.1002/hed.10274
Carol R. Bradford, Shao-Bo Zhu, Haruko Ogawa, Tetsuya Ogawa, Matthew Ubell, Ajita Narayan, Garfield Johnson, Gregory T. Wolf, Susan G. Fisher, Thomas E. Carey;
p53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.
Head Neck 25:654-661(2003)

PubMed=14720192; DOI=10.1111/j.1600-0714.2004.00157.x
Ian C. Mackenzie;
Growth of malignant oral epithelial stem cells after seeding into organotypical cultures of normal mucosa.
J. Oral Pathol. Med. 33:71-78(2004)

PubMed=16020667; DOI=10.1158/1535-7163.MCT-05-0081
Joshua A. Bauer, Douglas K. Trask, Bhavna Kumar, Gerrit Los, Jason Castro, Julia Shin-Jung Lee, Jian-Yong Chen, Shao-Meng Wang, Carol R. Bradford, Thomas E. Carey;
Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.
Mol. Cancer Ther. 4:1096-1104(2005)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176
J. Chad Brenner, Martin P. Graham, Bhavna Kumar, Lindsay M. Saunders, Robbi Kupfer, Robert H. Lyons, Carol R. Bradford, Thomas E. Carey;
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7762
Anatomy/cell type resources BTO; BTO_0004023
Encyclopedic resources Wikidata; Q54990881
Polymorphism and mutation databases IARC_TP53; 18874
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22