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Cellosaurus UM-SCC-47 (CVCL_7759)

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Cell line name UM-SCC-47
Synonyms UMSCC-47; UMSCC47; UM-SCC47; UM:SCC047; UMSCC047; University of Michigan-Squamous Cell Carcinoma-47
Accession CVCL_7759
Resource Identification Initiative To cite this cell line use: UM-SCC-47 (RRID:CVCL_7759)
Comments Part of: MD Anderson Cell Lines Project.
Part of: OPC-22 oral and pharyngeal cancer cell line panel.
Virology: Contains from 21 to 47 copies of the HPV16 genome (PubMed=24201445).
Doubling time: 2.2 days (PubMed=29156801).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing; Low read coverage.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Omics: Variations; CNV analysis.
Misspelling: UPCI:SCC47; GEO=GSM937830; GEO=GSM937831.
Derived from site: In situ; Oral cavity, tongue, lateral border; UBERON=UBERON_0011877.
Sequence variations
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Gly192Ter (c.574G>T); Zygosity=Homozygous (PubMed=31541927).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=12884349).
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC071; PubMed=19760794; PubMed=21868764; PubMed=25275298; PubMed=29156801; PubMed=33802339

Markers:
AmelogeninX,Y
CSF1PO11,13
D2S133825
D3S135815
D5S81811,12
D7S82011
D8S117915
D13S3178,11
D16S5398,13
D18S5118
D19S43314,15
D21S1129,30
FGA23,25
Penta D9,10
Penta E12,13
TH017,9.3
TPOX10,11
vWA18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Provider; AHNS; -; https://www.ahns.info/view/research-cell-lines-view/entry/24336/
Publications

PubMed=12884349; DOI=10.1002/hed.10274
Carol R. Bradford, Shao-Bo Zhu, Haruko Ogawa, Tetsuya Ogawa, Matthew Ubell, Ajita Narayan, Garfield Johnson, Gregory T. Wolf, Susan G. Fisher, Thomas E. Carey;
p53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.
Head Neck 25:654-661(2003)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082
Wendell Gray Yarbrough, Amy Whigham, Brandee Brown, Michael Roach, Robbert J.C. Slebos;
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007)

PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176
J. Chad Brenner, Martin P. Graham, Bhavna Kumar, Lindsay M. Saunders, Robbi Kupfer, Robert H. Lyons, Carol R. Bradford, Thomas E. Carey;
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=23419152; DOI=10.1186/gm419; PMCID=PMC3706778
Matthias Lechner, Tim R. Fenton, James West, Gareth Wilson, Andrew Feber, Stephen Henderson, Christina Thirlwell, Harpreet K. Dibra, Amrita Jay, Lee M. Butcher, Ankur Ravinarayana Chakravarthy ...Show all 19 authors... , Fiona Gratrix, Nirali Patel, Francis Vaz, Paul O'Flynn, Nicholas Kalavrezos, Andrew Erich Teschendorff, Chris Boshoff, Stephan Beck; Show fewer authors
Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma.
Genome Med. 5:15.1-15.16(2013)

PubMed=24201445; DOI=10.1101/gr.164806.113; PMCID=PMC3912410
Keiko Akagi, Jing-Feng Li, Tatevik R. Broutian, Hesed Maria Padilla-Nash, Wei-Hong Xiao, Bo Jiang, James W. Rocco, Theodoros Null Teknos, Bhavna Kumar, Danny Wangsa, Dan He ...Show all 14 authors... , Thomas Ried, David E. Symer, Maura Lianne Gillison; Show fewer authors
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Genome Res. 24:185-199(2014)

PubMed=25275298; DOI=10.18632/oncotarget.2417; PMCID=PMC4253406
Daniel Martin, Martin C. Abba, Alfredo Alberto Molinolo, Lynn Vitale-Cross, Zhi-Yong Wang, Moraima Zaida, Naomi C. Delic, Yardena Samuels, J. Guy Lyons, J. Silvio Gutkind;
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

PubMed=26045983; PMCID=PMC4449432
Frank Ziemann, Andrea Arenz, Stefanie Preising, Claus Wittekindt, Jens Peter Klussmann, Rita Engenhart-Cabillic, Andrea Wittig;
Increased sensitivity of HPV-positive head and neck cancer cell lines to X-irradiation +/- cisplatin due to decreased expression of E6 and E7 oncoproteins and enhanced apoptosis.
Am. J. Cancer Res. 5:1017-1031(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28236344; DOI=10.1002/hed.24729; PMCID=PMC5392184
Heather M. Walline, Christine Marie Goudsmit, Jonathan B. McHugh, Alice L. Tang, John Henry Owen, Bin Tean Teh, Erin L. McKean, Thomas W. Glover, Martin P. Graham, Mark Edward P. Prince, Douglas Brian Chepeha ...Show all 19 authors... , Steven B. Chinn, Robert Louis Ferris, Susanne M. Gollin, Thomas K. Hoffmann, Henning Bier, Ruud H. Brakenhoff, Carol R. Bradford, Thomas E. Carey; Show fewer authors
University of Michigan Head and Neck Specialized Program of Research Excellence (SPORE) Program
Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines.
Head Neck 39:840-852(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004; PMCID=PMC7372097
Anne M. van Harten, Jos B. Poell, Marijke Buijze, Arjen Brink, Susanne I. Wells, C. Rene Leemans, Rob M.F. Wolthuis, Ruud H. Brakenhoff;
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Oral Oncol. 98:53-61(2019)

PubMed=32574978; DOI=10.1016/j.tranon.2020.100808; PMCID=PMC7317296
Thankam S. Nair, Trey B. Thomas, Lucy Yang, Bala Naveen Kakaraparthi, Anna C. Morris, Alanna M. Clark, Lora Perry Campredon, Andrew F. Brouwer, Marisa C. Eisenberg, Rafael Meza, Thomas E. Carey;
Characteristics of head and neck squamous cell carcinoma cell lines reflect human tumor biology independent of primary etiologies and HPV status.
Transl. Oncol. 13:100808.1-100808.9(2020)

PubMed=33802339; DOI=10.3390/cancers13051069; PMCID=PMC7959143
Eva-Leonne Gottgens, Marleen Ansems, William P.J. Leenders, Johan Bussink, Paul N. Span;
Genotyping and characterization of HPV status, hypoxia, and radiosensitivity in 22 head and neck cancer cell lines.
Cancers (Basel) 13:1069.1-1069.12(2021)

Cross-references
Cell line collections (Providers) Millipore; SCC071
Cell line databases/resources cancercelllines; CVCL_7759
Encyclopedic resources Wikidata; Q54990870
Gene expression databases GEO; GSM937830
GEO; GSM937831
GEO; GSM3631278
Polymorphism and mutation databases Cosmic; 1122677
Cosmic; 2131865
Cosmic; 2296309
IARC_TP53; 21103
Progenetix; CVCL_7759
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28