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Cellosaurus UM-SCC-3 (CVCL_7740)

[Text version]
Cell line name UM-SCC-3
Synonyms UMSCC-3; UMSCC3; SCC3; University of Michigan-Squamous Cell Carcinoma-3
Accession CVCL_7740
Resource Identification Initiative To cite this cell line use: UM-SCC-3 (RRID:CVCL_7740)
Comments Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
Disease Head and neck squamous cell carcinoma (NCIt: C34447)
Squamous cell carcinoma of the nasal cavity and paranasal sinuses (ORDO: Orphanet_500464)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 73Y
Category Cancer cell line
STR profile Source(s): PubMed=19760794; PubMed=21868764

Markers:
AmelogeninX
CSF1PO10,12
D3S135817
D5S81811,13
D7S8209,10
D8S117914
D13S31711,13
D16S53911,12
D18S5112,15
D21S1131.2
FGA20,27
TH016,9.3
TPOX8
vWA17

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Publications

PubMed=3855324; DOI=10.1288/00005537-198501000-00012
Shan R. Baker;
An in vivo model for squamous cell carcinoma of the head and neck.
Laryngoscope 95:43-56(1985)

PubMed=1851275; DOI=10.1177/019459989110400304
Carol R. Bradford, Susan E. Zacks, Elliot J. Androphy, Lucie Gregoire, Wayne D. Lancaster, Thomas E. Carey;
Human papillomavirus DNA sequences in cell lines derived from head and neck squamous cell carcinomas.
Otolaryngol. Head Neck Surg. 104:303-310(1991)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=16035614; DOI=10.1007/s10585-004-6918-5
Robert Mandic, Thomas Ludwig, Hans Oberleithner, Jochen Alfred Werner;
Evaluation of head and neck squamous cell carcinoma invasiveness by the electrical resistance breakdown assay.
Clin. Exp. Metastasis 21:699-704(2004)

PubMed=16203773; DOI=10.1158/1078-0432.CCR-05-0378
Robert Mandic, Chantal J. Schamberger, Julia F. Muller, Matthias Geyer, Li Zhu, Thomas E. Carey, Reidar Grenman, Anja A. Dunne, Jochen Alfred Werner;
Reduced cisplatin sensitivity of head and neck squamous cell carcinoma cell lines correlates with mutations affecting the COOH-terminal nuclear localization signal of p53.
Clin. Cancer Res. 11:6845-6852(2005)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176
J. Chad Brenner, Martin P. Graham, Bhavna Kumar, Lindsay M. Saunders, Robbi Kupfer, Robert H. Lyons, Carol R. Bradford, Thomas E. Carey;
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7740
Encyclopedic resources Wikidata; Q54990847
Polymorphism and mutation databases Cosmic; 1130350
Cosmic; 1483456
IARC_TP53; 21636
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number23