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Cellosaurus UM-SCC-25 (CVCL_7735)

[Text version]
Cell line name UM-SCC-25
Synonyms UMSCC-25; UMSCC25; SCC25; UMC-25; UMC25; University of Michigan-Squamous Cell Carcinoma-25
Accession CVCL_7735
Resource Identification Initiative To cite this cell line use: UM-SCC-25 (RRID:CVCL_7735)
Comments Part of: MD Anderson Cell Lines Project.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Omics: Variations; CNV analysis.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): PubMed=19760794; PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO10,15
D3S135816
D5S81812
D7S82012,13
D8S117913,14
D13S31711
D16S53910,12
D18S5119
D21S1127
FGA21
TH016,9
TPOX8,9
vWA19

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=12884349; DOI=10.1002/hed.10274
Carol R. Bradford, Shao-Bo Zhu, Haruko Ogawa, Tetsuya Ogawa, Matthew Ubell, Ajita Narayan, Garfield Johnson, Gregory T. Wolf, Susan G. Fisher, Thomas E. Carey;
p53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.
Head Neck 25:654-661(2003)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176
J. Chad Brenner, Martin P. Graham, Bhavna Kumar, Lindsay M. Saunders, Robbi Kupfer, Robert H. Lyons, Carol R. Bradford, Thomas E. Carey;
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=31090975; DOI=10.1002/hed.25803; PMCID=PMC6692232
Jacqueline E. Mann, Aditi Kulkarni, Andrew C. Birkeland, Judy Kafelghazal, Julia Eisenberg, Brittany M. Jewell, Megan L. Ludwig, Matthew Edward Spector, Hui Jiang, Thomas E. Carey, J. Chad Brenner;
The molecular landscape of the University of Michigan laryngeal squamous cell carcinoma cell line panel.
Head Neck 41:3114-3124(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7735
Encyclopedic resources Wikidata; Q54990841
Gene expression databases GEO; GSM960575
GEO; GSM960577
GEO; GSM960579
GEO; GSM960581
GEO; GSM960583
GEO; GSM960586
GEO; GSM960588
GEO; GSM3631272
Polymorphism and mutation databases Cosmic; 1130359
Cosmic; 2131863
IARC_TP53; 21102
Progenetix; CVCL_7735
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number24