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Cellosaurus UM-SCC-19 (CVCL_7727)

[Text version]
Cell line name UM-SCC-19
Synonyms UMSCC-19; UMSCC 19; UMSCC19; UMC19; UMC-19; umc-19; University of Michigan-Squamous Cell Carcinoma-19
Accession CVCL_7727
Resource Identification Initiative To cite this cell line use: UM-SCC-19 (RRID:CVCL_7727)
Comments Part of: MD Anderson Cell Lines Project.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Omics: Variations; CNV analysis.
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): PubMed=19760794; PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO11
D3S135814
D5S81811
D7S8209
D8S117910,12
D13S31711
D16S5399,13
D18S5110,16
D21S1128,30
FGA24
TH016,7
TPOX8,11
vWA16,19

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=3855324; DOI=10.1288/00005537-198501000-00012
Shan R. Baker;
An in vivo model for squamous cell carcinoma of the head and neck.
Laryngoscope 95:43-56(1985)

PubMed=1851275; DOI=10.1177/019459989110400304
Carol R. Bradford, Susan E. Zacks, Elliot J. Androphy, Lucie Gregoire, Wayne D. Lancaster, Thomas E. Carey;
Human papillomavirus DNA sequences in cell lines derived from head and neck squamous cell carcinomas.
Otolaryngol. Head Neck Surg. 104:303-310(1991)

PubMed=1394225
Kenneth D. Somers, M. Anne Merrick, Martha E. Lopez, Leonard S. Incognito, Gary L. Schechter, Graham Casey;
Frequent p53 mutations in head and neck cancer.
Cancer Res. 52:5997-6000(1992)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=8552396
Ankita M. Patel, Leonard S. Incognito, Gary L. Schechter, William J. Wasilenko, Kenneth D. Somers;
Amplification and expression of EMS-1 (cortactin) in head and neck squamous cell carcinoma cell lines.
Oncogene 12:31-35(1996)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176
J. Chad Brenner, Martin P. Graham, Bhavna Kumar, Lindsay M. Saunders, Robbi Kupfer, Robert H. Lyons, Carol R. Bradford, Thomas E. Carey;
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939
Hiroshi Hyakusoku, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Yasuhiro Isono, Shoko Shimada, Yusuke Ito, Jeffrey N. Myers, Nobuhiko Oridate;
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7727
Encyclopedic resources Wikidata; Q54990831
Gene expression databases GEO; GSM3631270
Polymorphism and mutation databases Cosmic; 844589
Cosmic; 877398
Cosmic; 1152493
Cosmic; 2043900
Cosmic; 2439755
Progenetix; CVCL_7727
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number20