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Cellosaurus UM-SCC-11A (CVCL_7715)

[Text version]
Cell line name UM-SCC-11A
Synonyms UMSCC-11A; UMSCC11A; University of Michigan-Squamous Cell Carcinoma-11A
Accession CVCL_7715
Resource Identification Initiative To cite this cell line use: UM-SCC-11A (RRID:CVCL_7715)
Comments Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Omics: Variations; CNV analysis.
Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Sequence variations
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_7716 ! UM-SCC-11B
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): PubMed=19760794; PubMed=21868764

Markers:
AmelogeninX
CSF1PO7
D3S135816
D5S81811
D7S82011
D8S117912,15
D13S31714
D16S53912,14
D18S5116
D21S1128
FGA19,24
TH017
TPOX8
vWA16,17,18

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Publications

PubMed=3855324; DOI=10.1288/00005537-198501000-00012
Shan R. Baker;
An in vivo model for squamous cell carcinoma of the head and neck.
Laryngoscope 95:43-56(1985)

PubMed=1851275; DOI=10.1177/019459989110400304
Carol R. Bradford, Susan E. Zacks, Elliot J. Androphy, Lucie Gregoire, Wayne D. Lancaster, Thomas E. Carey;
Human papillomavirus DNA sequences in cell lines derived from head and neck squamous cell carcinomas.
Otolaryngol. Head Neck Surg. 104:303-310(1991)

PubMed=1958593; DOI=10.1002/gcc.2870030406
Carol R. Bradford, Kathryn Anne Kimmel, Daniel L. Van Dyke, Maria J. Worsham, Barbara J. Tilley, David Burk, Fernando del Rosario, Stephen Lutz, Richard Tooley, Diana J.S. Hayashida, Thomas E. Carey;
11p deletions and breakpoints in squamous cell carcinoma: association with altered reactivity with the UM-E7 antibody.
Genes Chromosomes Cancer 3:272-282(1991)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=15287027; DOI=10.1002/gcc.20066
Satoru Takebayashi, Arthur Hickson, Tetsuya Ogawa, Kwang-Yoon Jung, Hiroyuki Mineta, Yo Ueda, Reidar Grenman, Susan G. Fisher, Thomas E. Carey;
Loss of chromosome arm 18q with tumor progression in head and neck squamous cancer.
Genes Chromosomes Cancer 41:145-154(2004)

PubMed=16785414; DOI=10.1001/archotol.132.6.668
Maria J. Worsham, Kang Mei Chen, Venkata Meduri, Anders O.H. Nygren, Abdellatif Errami, Jan P. Schouten, Michael S. Benninger;
Epigenetic events of disease progression in head and neck squamous cell carcinoma.
Arch. Otolaryngol. Head Neck Surg. 132:668-677(2006)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=18006756; DOI=10.1158/1078-0432.CCR-07-1591
Jay Friedman, Liesl K. Nottingham, Praveen Duggal, Francisco G. Pernas, Bin Yan, Xin-Ping Yang, Zhong Chen, Carter Van Waes;
Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer.
Clin. Cancer Res. 13:6568-6578(2007)

PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176
J. Chad Brenner, Martin P. Graham, Bhavna Kumar, Lindsay M. Saunders, Robbi Kupfer, Robert H. Lyons, Carol R. Bradford, Thomas E. Carey;
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=31090975; DOI=10.1002/hed.25803; PMCID=PMC6692232
Jacqueline E. Mann, Aditi Kulkarni, Andrew C. Birkeland, Judy Kafelghazal, Julia Eisenberg, Brittany M. Jewell, Megan L. Ludwig, Matthew Edward Spector, Hui Jiang, Thomas E. Carey, J. Chad Brenner;
The molecular landscape of the University of Michigan laryngeal squamous cell carcinoma cell line panel.
Head Neck 41:3114-3124(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7715
Encyclopedic resources Wikidata; Q54990807
Gene expression databases GEO; GSM3631266
Polymorphism and mutation databases Cosmic; 948027
Cosmic; 2131860
IARC_TP53; 25907
Progenetix; CVCL_7715
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25