Cellosaurus cell line (CVCL

Entry history
Comments	Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: Plasma cell; CL=CL_0000786.
Sequence variations	Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
Disease	Plasma cell myeloma (NCIt: C3242) Multiple myeloma (ORDO: Orphanet_29073)
Species of origin	Rattus norvegicus (Rat) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0014 (RPMI-8226)
Sex of cell	Male
Age at sampling	61Y
Category	Cancer cell line
Entry creation	19-Dec-2024
Last entry update	14-Aug-2025
Version number	3