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Cellosaurus DEV [Human lymphoma] (CVCL_7187)

[Text version]
Cell line name DEV [Human lymphoma]
Accession CVCL_7187
Resource Identification Initiative To cite this cell line use: DEV [Human lymphoma] (RRID:CVCL_7187)
Comments Problematic cell line: Misclassified. Originally thought to be a Hodgkin lymphoma cell line, but seems to be from a nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL).
Doubling time: ~3 days (PubMed=3881158).
Omics: SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Disease Nodular lymphocyte predominant Hodgkin lymphoma (NCIt: C7258)
Nodular lymphocyte predominant Hodgkin lymphoma (ORDO: Orphanet_86893)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line

PubMed=3881158; DOI=10.1002/1097-0142(19850215)55:4<683::AID-CNCR2820550402>3.0.CO;2-O
Poppema S., de Jong B., Atmosoerodjo J., Idenburg V., Visser L., de Leij L.F.M.H.
Morphologic, immunologic, enzymehistochemical and chromosomal analysis of a cell line derived from Hodgkin's disease. Evidence for a B-cell origin of Sternberg-Reed cells.
Cancer 55:683-690(1985)

PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5
Schaadt M., Burrichter H., Pfreundschuh M., Schell-Frederick E., Tesch H., Fonatsch C., Stein H., Diehl V.
Biology of Hodgkin cell lines.
Recent Results Cancer Res. 117:53-61(1989)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12581897; DOI=10.1016/S0165-4608(02)00656-8
Berglund M., Flordal E., Gullander J., Lui W.-O., Larsson C., Lagercrantz S., Enblad G.
Molecular cytogenetic characterization of four commonly used cell lines derived from Hodgkin lymphoma.
Cancer Genet. Cytogenet. 141:43-48(2003)

PubMed=19648161; DOI=10.3324/haematol.2009.010157
Schumacher M.A., Schmitz R., Brune V., Tiacci E., Doring C., Hansmann M.-L., Siebert R., Kuppers R.
Mutations in the genes coding for the NF-kappaB regulating factors IkappaBalpha and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma.
Haematologica 95:153-157(2010)

PubMed=27998726; DOI=10.1016/j.ajpath.2016.10.007
Fromm J.R., Thomas A., Wood B.L.
Characterization and purification of neoplastic cells of nodular lymphocyte predominant Hodgkin lymphoma from lymph nodes by flow cytometry and flow cytometric cell sorting.
Am. J. Pathol. 187:304-317(2017)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Drexler H.G., Pommerenke C., Eberth S., Nagel S.
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

Cell line databases/resources Lonza; 268
Encyclopedic resources Wikidata; Q54831018
Gene expression databases GEO; GSM1897960
Polymorphism and mutation databases Cosmic; 1293254
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number17