Cellosaurus cell line MR-Mel (CVCL

Cross-references
Cell line name	MR-Mel
Accession	CVCL_7081
Resource Identification Initiative	To cite this cell line use: MR-Mel (RRID:CVCL_7081)
Comments	Derived from site: Metastatic; Not specified.
Sequence variations	Gene deletion; HGNC; HGNC:583; APC; Zygosity=Homozygous (PubMed=18384130). Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Gln939Ter (c.2815C>T); ClinVar=VCV000089318; Zygosity=Unspecified (PubMed=18384130). Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Thr1008Ile (c.3023C>T); ClinVar=VCV000569009; Zygosity=Unspecified (PubMed=18384130).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=18384130; DOI=10.1002/gcc.20567 Daniele Castiglia, Silvia Bernardini, Ester Alvino, Elena Pagani, Naomi De Luca, Sabrina Falcinelli, Alberto Pacchiarotti, Enzo Bonmassar, Giovanna Zambruno, Stefania D'Atri; Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma. Genes Chromosomes Cancer 47:614-624(2008)
Anatomy/cell type resources	BTO; BTO_0003790
Encyclopedic resources	Wikidata; Q54906566
Polymorphism and mutation databases	Cosmic; 1109799
Entry history
Entry creation	04-Apr-2012
Last entry update	14-Aug-2025
Version number	10