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Cellosaurus MB-02 (CVCL_7075)

[Text version]
Cell line name MB-02
Synonyms MB02; MBO2
Accession CVCL_7075
Resource Identification Initiative To cite this cell line use: MB-02 (RRID:CVCL_7075)
Comments Problematic cell line: Partially contaminated. Some stocks were contaminated by HU-3 (PubMed=10516762).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00165.
Characteristics: CSF2 dependent.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 6192; JAK2; Simple; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Homozygous (PubMed=16408098).
Disease Adult acute megakaryoblastic leukemia (NCIt: C7965)
Acute megakaryoblastic leukemia (ORDO: Orphanet_518)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=1954374; DOI=10.1182/blood.V78.11.2860.2860
Morgan D.A., Gumucio D.L., Brodsky I.
Granulocyte-macrophage colony-stimulating factor-dependent growth and erythropoietin-induced differentiation of a human cell line MB-02.
Blood 78:2860-2871(1991)

PubMed=9096695; DOI=10.1038/sj.leu.2400621
Drexler H.G., Zaborski M., Quentmeier H.
Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.
Leukemia 11:541-551(1997)

PubMed=10516762; DOI=10.1038/sj.leu.2401510
Drexler H.G., Dirks W.G., MacLeod R.A.F.
False human hematopoietic cell lines: cross-contaminations and misinterpretations.
Leukemia 13:1601-1607(1999)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

Cell line databases/resources cancercelllines; CVCL_7075
Anatomy/cell type resources BTO; BTO:0004767
Encyclopedic resources Wikidata; Q54904079
Gene expression databases GEO; GSM743417
Polymorphism and mutation databases Cosmic; 787449
Cosmic; 924045
Cosmic; 975267
Cosmic; 1012052
Cosmic; 1012084
Cosmic; 1281325
Cosmic; 1465957
Cosmic; 2306216
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number21