Cellosaurus cell line GIST522 (CVCL

Cellosaurus GIST522 (CVCL_7042)

Cross-references
Cell line name	GIST522
Synonyms	GIST-522
Accession	CVCL_7042
Resource Identification Initiative	To cite this cell line use: GIST522 (RRID:CVCL_7042)
Comments	Cell type: Interstitial cell of Cajal; CL=CL_0002088.
Sequence variations	Mutation; HGNC; HGNC:6342; KIT; Simple; p.Glu554_Lys558del (c.1661_1675del); Zygosity=Heterozygous (PubMed=19706776).
Disease	Gastrointestinal stromal tumor (NCIt: C3868) Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category	Cancer cell line
Publications	PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004; PMCID=PMC2905726 Thomas Muhlenberg, Yi-Xiang Zhang, Andrew J. Wagner, Florian Grabellus, James E. Bradner, Georg Taeger, Hauke Lang, Takahiro Taguchi, Martin Schuler, Jonathan A. Fletcher, Sebastian Bauer; Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors. Cancer Res. 69:6941-6950(2009) PubMed=30488756; DOI=10.1080/15384101.2018.1553335; PMCID=PMC6300111 Yu-Qing Tu, Rui Zuo, Nan Ni, Grant Eilers, Duo-Lin Wu, Yu-Ting Pei, Zuo-Ming Nie, Ye-Qing Wu, Yue-Hong Wu, Wen-Bin Ou; Activated tyrosine kinases in gastrointestinal stromal tumor with loss of KIT oncoprotein expression. Cell Cycle 17:2577-2592(2018)
Cell line databases/resources	cancercelllines; CVCL_7042
Encyclopedic resources	Wikidata; Q54835860
Gene expression databases	GEO; GSM486231
Polymorphism and mutation databases	Cosmic; 1180676 Progenetix; CVCL_7042
Entry history
Entry creation	04-Apr-2012
Last entry update	19-Dec-2024
Version number	15