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Cellosaurus IIICF-T/C3 (CVCL_6F13)

[Text version]
Cell line name IIICF-T/C3
Synonyms LTAG-transformed IIICF clone C3
Accession CVCL_6F13
Resource Identification Initiative To cite this cell line use: IIICF-T/C3 (RRID:CVCL_6F13)
Comments Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pRSV-T).
Derived from site: In situ; Breast, stroma; UBERON=UBERON_0003584.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Thr125Thr (c.375G>A); ClinVar=VCV000177825; Zygosity=Hemizygous; Note=Impairs TP53 splicing dramatically (from parent cell line).
Disease Li-Fraumeni syndrome (NCIt: C3476)
Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4415 (IIICF/c)
Sex of cell Female
Age at sampling 30-40Y
Category Transformed cell line
Publications

PubMed=8108114
Kenneth MacLean, Eileen M. Rogan, Noel J. Whitaker, Andy C.-M. Chang, Peter B. Rowe, Luciano Dalla-Pozza, Geoff Symonds, Roger Robert Reddel;
In vitro transformation of Li-Fraumeni syndrome fibroblasts by SV40 large T antigen mutants.
Oncogene 9:719-725(1994)

PubMed=9175740; DOI=10.1093/hmg/6.6.921
Tracy M. Bryan, Lidija Marusic, Silvia Bacchetti, Masayoshi Namba, Roger Robert Reddel;
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit.
Hum. Mol. Genet. 6:921-926(1997)

Cross-references
Encyclopedic resources Wikidata; Q54897433
Entry history
Entry creation23-Feb-2016
Last entry update14-Aug-2025
Version number14