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Cellosaurus (CVCL_6D57)

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Comments Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Basophil progenitor cell; CL=CL_0000613.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:76; ABL1; Simple; p.Phe359Cys (c.1076T>G); dbSNP=rs1057519775; Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=21718141).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Arg (c.395A>G); ClinVar=VCV000376625; Zygosity=Homozygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0379 (Ku812)
Sex of cell Male
Age at sampling 38Y
Category Cancer cell line
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1