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Cellosaurus T1-A (CVCL_6C57)

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Cell line name T1-A
Accession CVCL_6C57
Resource Identification Initiative To cite this cell line use: T1-A (RRID:CVCL_6C57)
Comments Characteristics: Highly tumorigenic. Obtained by subcutaneous hind quarter injection of parent cell line (GhrasT-NIH/3T3) in NIH Swiss mice and selection of cells from a hind quarter tumor.
Doubling time: 17.5 hours (PubMed=26254261).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Derived from site: In situ; Whole embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: NIH Swiss.
Hierarchy Parent: CVCL_WS34 (GhrasT-NIH/Swiss)
Children:
CVCL_6C58 (T2-A)
Sex of cell Male
Age at sampling Embryo
Category Transformed cell line
Publications

PubMed=26254261; DOI=10.1016/j.yexcr.2015.07.029
Durwood B. Ray, Gerald A. Merrill, Frederic J. Brenner, Laurie S. Lytle, Tan Lam, Aaron McElhinney, Joel Anders, Tara Tauber Rock, Jennifer Kier Lyker, Scott Barcus, Kara Hust Leslie ...Show all 31 authors... , Jill M. Kramer, Eric M. Rubenstein, Karen Pryor Schanz, Amy J. Parkhurst, Michelle Peck, Kimberly Good, Kristi Lemke Granath, Nicole Cifra, Jessalee Wantz Detweiler, Laura Stevens, Richard Albertson, Rachael Deir, Elisabeth Stewart, Katherine Wingard, Micah Rose Richardson, Sarah B. Blizard, Lauren E. Gillespie, Charles E. Kriley, Daniel I. Rzewnicki, David H. Jones; Show fewer authors
T24 HRAS transformed NIH/3T3 mouse cells (GhrasT-NIH/3T3) in serial tumorigenic in vitro/in vivo passages give rise to increasingly aggressive tumorigenic cell lines T1-A and T2-A and metastatic cell lines T3-HA and T4-PA.
Exp. Cell Res. 340:1-11(2016)

Cross-references
Cell line collections (Providers) ABM; T8144
Encyclopedic resources Wikidata; Q54971396
Entry history
Entry creation23-Feb-2016
Last entry update27-Nov-2025
Version number12