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Cellosaurus OMM-1 (CVCL_6939)

[Text version]
Cell line name OMM-1
Synonyms OMM1; Omm1
Accession CVCL_6939
Resource Identification Initiative To cite this cell line use: OMM-1 (RRID:CVCL_6939)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 34 hours (PubMed=24994677).
Omics: Proteomics.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Sequence variations
Disease Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-002017; PubMed=22236444; PubMed=24994677

Markers:
AmelogeninX
CSF1PO10,12
D3S135814,17
D5S81811
D7S82013
D8S117910,16
D13S31711,12 (PubMed=22236444)
12 (DepMap=ACH-002017; PubMed=24994677)
D16S5399
D18S5113,14
D21S1130,30.2
FGA20
Penta D9,12
Penta E5,7
TH017
TPOX8,9
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=8621261; DOI=10.1002/(SICI)1097-0215(19960503)66:3<380::AID-IJC19>3.0.CO;2-F
Gregorius P.M. Luyten, Nicole C. Naus, Cornelia M. Mooy, Anne Hagemeijer, June Kan-Mitchell, Ellen van Drunen, Vojislav Vuzevski, Paulus T.V.M. de Jong, Theo M. Luider;
Establishment and characterization of primary and metastatic uveal melanoma cell lines.
Int. J. Cancer 66:380-387(1996)

PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016
Jason S. White, Robert L. Becker, Ian W. McLean, Alison E. Director-Myska, Joginder Nath;
Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.
Cancer Genet. Cytogenet. 168:11-21(2006)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x; PMCID=PMC3288394
Klaus Georg Griewank, Xiao-Xing Yu, Jahan S. Khalili, Mustafa Mert Sozen, Katherine Stemke-Hale, Chantale Bernatchez, Seth Wardell, Boris C. Bastian, Scott E. Woodman;
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011
Adriana Amaro, Valentina Mirisola, Giovanna Angelini, Alessandra Musso, Francesca Isabella Tosetti, Alessia Isabella Esposito, Patrizia Perri, Francesco Baldo Lanza, Francesca Nasciuti, Carlo Mosci, Roberto Puzone ...Show all 15 authors... , Sandra Salvi, Mauro Truini, Alessandro Poggi, Ulrich Pfeffer; Show fewer authors
Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity.
Eur. J. Cancer 49:3353-3365(2013)

PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590
Nabil Amirouchene-Angelozzi, Fariba Nemati, David Gentien, Andre Nicolas, Amaury Dumont, Guillaume Carita, Jacques Camonis, Laurence Desjardins, Nathalie Cassoux, Sophie Piperno-Neumann, Pascale Mariani ...Show all 14 authors... , Xavier Sastre-Garau, Didier Decaudin, Sergio Roman-Roman; Show fewer authors
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Mol. Oncol. 8:1508-1520(2014)

PubMed=39042403; DOI=10.1167/iovs.65.8.37; PMCID=PMC11268447
Maria Chiara Gelmi, Arnoud H. de Ru, Peter A. van Veelen, Rayman T.N. Tjokrodirijo, Marc-Henri Stern, Alexandre Houy, Robert M. Verdijk, T.H. Khanh Vu, Bruce R. Ksander, Jolanda Vaarwater, Emine Kilic ...Show all 13 authors... , Erwin Brosens, Martine Johanna Jager; Show fewer authors
Protein and mRNA expression in uveal melanoma cell lines are related to GNA and BAP1 mutation status.
Invest. Ophthalmol. Vis. Sci. 65:37-37(2024)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6939
DepMap; ACH-002017
Encyclopedic resources Wikidata; Q54936368
Polymorphism and mutation databases Cosmic; 848331
Cosmic; 899895
Cosmic; 916147
Cosmic; 1628402
Cosmic; 1669126
Cosmic; 2036704
Proteomic databases PRIDE; PXD051055
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number27