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Cellosaurus CNE-1 (CVCL_6888)

[Text version]
Cell line name CNE-1
Synonyms CNE1; CNE
Accession CVCL_6888
Secondary accession CVCL_6887
Resource Identification Initiative To cite this cell line use: CNE-1 (RRID:CVCL_6888)
Comments Problematic cell line: Contaminated. On the basis of the STR profile (PubMed=18196576) it is identical to CNE-2 and seems to be a hybrid of HeLa and of cell line of unknown origin. This is also confirmed by RNASeq data from PubMed=24991015. Originally thought to originate from a 58 year old female patient with a nasopharyngeal carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00473.
Omics: Transcriptomics; RNAseq.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_YT53 (CNE1 SRPK1 KO)CVCL_YT54 (CNE1 SRPK2 KO)CVCL_D8FM (Ubigene CNE-1 SETD2 KO)
Category Hybrid cell line
STR profile Source(s): PubMed=18196576

Markers:
AmelogeninX
CSF1PO10,11
D2S133817,23
D3S135815,18
D5S81811,12
D7S82010,12
D8S117912,16
D13S31710,12,13.3
D16S5399,10
D18S5113,16
D19S43313
D21S1127,30
FGA18,21
TH016,7,9
TPOX8,12
vWA14,16

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=206962; DOI=10.1360/ya1978-21-1-127
Y. Zeng;
Establishment of an epitheloid cell line and a fusiform cell line from a patient with nasopharyngeal carcinoma.
Sci. Sin. 21:127-134(1978)

PubMed=7129938; DOI=10.1111/j.1601-5223.1982.tb00706.x
Si-Zhong Zhang, Yin-Tang Wu, Yi Zeng, Lore Zech, George Klein;
Cytogenetic studies on an epithelioid cell line derived from nasopharyngeal carcinoma.
Hereditas 97:23-28(1982)

PubMed=1813165
Fang-Yi Kong, Jin Gao;
The invasive behavior of two human nasopharyngeal carcinoma (NPC) cell lines CNE-1, CNE-2Z in vitro.
Zhonghua Bing Li Xue Za Zhi 20:288-291(1991)

PubMed=12645650; DOI=10.1016/S0165-4608(02)00657-X
Nathalie Wong, Angela Bik-Yu Hui, Bo-Li Fan, Kwok-Wai Lo, Elizabeth Pang, Sing-Fai Leung, Dolly Wai-Sen Huang Poon, Philip James Johnson;
Molecular cytogenetic characterization of nasopharyngeal carcinoma cell lines and xenografts by comparative genomic hybridization and spectral karyotyping.
Cancer Genet. Cytogenet. 140:124-132(2003)

PubMed=18196576; DOI=10.1002/ijc.23374
Sylvia Yat-Yee Chan, Kwong-Wai Choy, George Sai-Wah Tsao, Qian Tao, Tao Tang, Grace Tin-Yun Chung, Kwok-Wai Lo;
Authentication of nasopharyngeal carcinoma tumor lines.
Int. J. Cancer 122:2169-2171(2008)

PubMed=24991015; DOI=10.1128/JVI.01457-14; PMCID=PMC4178894
Michael J. Strong, Melody Baddoo, Asuka Nanbo, Miao Xu, Adriane Puetter, Zhen Lin;
Comprehensive high-throughput RNA sequencing analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes.
J. Virol. 88:10696-10704(2014)

Cross-references
Cell line collections (Providers) CCTCC; GDC0208
Ubigene; YC-C062
Cell line databases/resources cancercelllines; CVCL_6888
TOKU-E; 3588
Anatomy/cell type resources BTO; BTO_0006074
Biological sample resources BioSample; SAMN06481108
Chemistry resources ChEMBL-Cells; CHEMBL3308055
ChEMBL-Targets; CHEMBL613824
PubChem_Cell_line; CVCL_6888
Encyclopedic resources Wikidata; Q54813873
Gene expression databases GEO; GSM375845
Polymorphism and mutation databases Cosmic; 755504
Cosmic; 923773
Cosmic; 944909
Cosmic; 1193457
Cosmic; 1322946
Cosmic; 2366879
Progenetix; CVCL_6888
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25