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Cellosaurus REF52 (CVCL_6848)

[Text version]
Cell line name REF52
Synonyms REF-52; REF 52; Rat Embryo Fibroblast 52
Accession CVCL_6848
Resource Identification Initiative To cite this cell line use: REF52 (RRID:CVCL_6848)
Comments Omics: Proteomics; 2DE.
Derived from site: In situ; Embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Fischer 344; RS=RS_0000215.
Hierarchy Children:
CVCL_GR59 (REF-4A)CVCL_B5G1 (REF-WT10A)CVCL_B5G2 (REF-WT1A)
CVCL_B5G3 (REF-WT2A)CVCL_B5G4 (REF-WT6A)
Sex of cell Sex unspecified
Age at sampling 14FD
Category Spontaneously immortalized cell line
Publications

PubMed=7314451; DOI=10.1016/0042-6822(81)90126-4
John Logan, Jean-Claude Nicolas, William C. Topp, Marc Paul Girard, Thomas Eugene Shenk, Arnold Jay Levine;
Transformation by adenovirus early region 2A temperature-sensitive mutants and their revertants.
Virology 115:419-422(1981)

PubMed=6133866; DOI=10.1016/S0021-9258(18)32460-8
Fumio Matsumura, Shigeko Yamashiro-Matsumura, Jim Jung-Ching Lin;
Isolation and characterization of tropomyosin-containing microfilaments from cultured cells.
J. Biol. Chem. 258:6636-6644(1983)

PubMed=6315714; DOI=10.1016/S0021-9258(17)44009-9
Fumio Matsumura, Jim Jung-Ching Lin, Shigeko Yamashiro-Matsumura, G. Paul Thomas, William C. Topp;
Differential expression of tropomyosin forms in the microfilaments isolated from normal and transformed rat cultured cells.
J. Biol. Chem. 258:13954-13964(1983)

PubMed=3510745; DOI=10.1016/0092-8674(86)90462-9
B. Robert Franza Jr., Kazuo Maruyama, James I. Garrels, H. Earl Ruley;
In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes.
Cell 44:409-418(1986)

PubMed=2830582
Nancy E. Kohl, H. Earl Ruley;
Role of c-myc in the transformation of REF52 cells by viral and cellular oncogenes.
Oncogene 2:41-48(1987)

PubMed=2564397; DOI=10.1016/S0021-9258(18)83730-9
James I. Garrels, B. Robert Franza Jr.;
Transformation-sensitive and growth-related changes of protein synthesis in REF52 cells. A two-dimensional gel analysis of SV40-, adenovirus-, and Kirsten murine sarcoma virus-transformed rat cells using the REF52 protein database.
J. Biol. Chem. 264:5299-5312(1989)

Cross-references
Cell line databases/resources TOKU-E; 3889
Anatomy/cell type resources BTO; BTO_0001955
Encyclopedic resources Wikidata; Q54949702
Experimental variables resources EFO; EFO_0022770
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number15