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Cellosaurus WM1366 (CVCL_6789)

[Text version]
Cell line name WM1366
Synonyms WM-1366; WM 1366; WC00078; EST70
Accession CVCL_6789
Resource Identification Initiative To cite this cell line use: WM1366 (RRID:CVCL_6789)
Comments Part of: MD Anderson Cell Lines Project.
Part of: Wistar Institute melanoma cell line collection.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in Cellosaurus and May 2018. The major changes were: CSF1PO: 11,12->12, D5S818: 12,13->13 and D7S820: 11,12->12.
Misspelling: Wn1366; Cosmic=1665010.
Derived from site: In situ; Forearm, skin; UBERON=UBERON_0003403.
Sequence variations
HLA typing Source: PubMed=15592718
Class I
HLA-AA*32:01,32:01
HLA-BB*41:01,41:01
HLA-CC*17:01,17:01
Class II
HLA-DPDPB1*03:01,03:01
HLA-DQDQB1*02:01,02:01
HLA-DRDRB1*03:01:02,03:01:02
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 79Y
Category Cancer cell line
STR profile Source(s): ESTDAB=ESTDAB-070; Wistar

Markers:
AmelogeninX
CSF1PO12
D2S133820,22
D3S135815,18
D5S81813
D7S82012
D8S117913,14
D13S3178,13
D16S53912,13
D18S5112,16
D19S43314,15
D21S1128,30
FGA21,22
TH016,7
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Wistar; -; https://www.wistar.org/our-scientists/meenhard-herlyn
Publications

PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966
Teresa Rodriguez, Rosa Mendez, Chrissy H. Roberts, Francisco Ruiz-Cabello Osuna, I. Anthony Dodi, Miguel Angel Lopez-Nevot, Laura Paco, Isabel Maleno, Steven G.E. Marsh, Graham Pawelec, Federico Garrido;
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Keith S. Hoek, Natalie C. Schlegel, Patricia Brafford, Antje Sucker, Selma Ugurel, Rajiv Kumar, Barbara L. Weber, Katherine L. Nathanson, Donald J. Phillips, Meenhard Herlyn, Dirk Schadendorf, Reinhard Dummer;
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Goran Jonsson, Christina Dahl, Johan Staaf, Troy Sandberg, Par-Ola Bendahl, Markus Ringner, Per Guldberg, Ake Borg;
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235; PMCID=PMC2615688
Keiran S.M. Smalley, Rooha Contractor, Thiennga K. Nguyen, Min Xiao, Robin Edwards, Viswanathan Muthusamy, Alastair J. King, Keith Thomas Flaherty, Marcus W. Bosenberg, Meenhard Herlyn, Katherine L. Nathanson;
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

PubMed=19340423; DOI=10.1007/s00262-009-0701-z; PMCID=PMC11030131
Rosa Mendez, Natalia Aptsiauri, Ana Del Campo, Isabel Maleno, Teresa Cabrera, Francisco Ruiz-Cabello Osuna, Federico Garrido, Angel Garcia-Lora;
HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.
Cancer Immunol. Immunother. 58:1507-1515(2009)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Christina Dahl, Claus Christensen, Goran Jonsson, Anders Lorentzen, Mette Louise Skjodt, Ake Borg, Graham Pawelec, Per Guldberg;
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=25502142; DOI=10.1038/ncomms6712; PMCID=PMC4428333
Judith Muller, Oscar Krijgsman, Jennifer Tsoi, Lidia Robert, Willy Hugo, Chunying Song, Xiang-Ju Kong, Patricia Abrao Possik, Paulien D.M. Cornelissen-Steijger, Marnix H. Geukes Foppen, Kristel Kemper ...Show all 19 authors... , Colin Ronald Goding, Ultan McDermott, Christian Blank, John B.A.G. Haanen, Thomas G. Graeber, Antoni Ribas, Roger S. Lo, Daniel S. Peeper; Show fewer authors
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.
Nat. Commun. 5:5712.1-5712.15(2014)

PubMed=25645078; DOI=10.1186/s12943-015-0293-5; PMCID=PMC4320814
Mohammad Atefi, Bjoern Titz, Earl Avramis, Charles Ng, Deborah J.L. Wong, Amanda Lassen, Michael Cerniglia, Helena Escuin-Ordinas, David Foulad, Begonya Comin-Anduix, Thomas G. Graeber, Antoni Ribas;
Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma.
Mol. Cancer 14:27.1-27.12(2015)

PubMed=25728708; DOI=10.1111/pcmr.12364
Celia J. Vogel, Marjon A. Smit, Gianluca Maddalo, Patricia Abrao Possik, Rolf W. Sparidans, Sjoerd H. van der Burg, Elizabeth M.E. Verdegaal, Albert J.R. Heck, Ahmed A. Samatar, Jos Heindrik Beijnen, A.F. Maarten Altelaar, Daniel S. Peeper;
Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.
Pigment Cell Melanoma Res. 28:307-317(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections (Providers) Coriell; WC00078 - Discontinued
Rockland; WM1366-01-0001
Cell line databases/resources cancercelllines; CVCL_6789
ESTDAB; ESTDAB-070
SKY/M-FISH/CGH; 4947
Encyclopedic resources Wikidata; Q54994172
Gene expression databases GEO; GSM109027
GEO; GSM185178
GEO; GSM185179
GEO; GSM185180
GEO; GSM185181
GEO; GSM188064
GEO; GSM188116
GEO; GSM188189
GEO; GSM188204
GEO; GSM188217
GEO; GSM188231
GEO; GSM188261
GEO; GSM188280
GEO; GSM188289
GEO; GSM188320
GEO; GSM952594
GEO; GSM1507941
Polymorphism and mutation databases Cosmic; 1047650
Cosmic; 1155539
Cosmic; 1665010
Cosmic; 2163800
IARC_TP53; 26077
Progenetix; CVCL_6789
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number37