Cellosaurus logo
expasy logo

Cellosaurus CHLA-136 (CVCL_6590)

[Text version]
Cell line name CHLA-136
Synonyms CHLA_136
Accession CVCL_6590
Resource Identification Initiative To cite this cell line use: CHLA-136 (RRID:CVCL_6590)
Comments Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
Doubling time: 53 hours (PubMed=20922763); 44 hours (COG).
Sequence variations
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A054 ! CHLA-122
Sex of cell Female
Age at sampling 3Y
Category Cancer cell line
STR profile Source(s): COG; PubMed=20922763

Markers:
AmelogeninX
CSF1PO10,11
D2S133823,25
D3S135815,18
D5S8189,12
D7S8208
D8S117910,13
D13S3178,11
D16S5399,12
D18S5112,18
D19S43313,14
D21S1131.2,32.2
FGA23,25
TH017
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Web pages Provider; CCR; -; https://www.cccells.org/PDF_Files/NB_Cell_Lines/CHLA-136%20Cell%20Line%20Data%20Sheet.pdf
Publications

PubMed=11212268
Patricia M. Thompson, John Matthew Maris, Michael D. Hogarty, Robert C. Seeger, Charles Patrick Reynolds, Garrett M. Brodeur, Peter S. White;
Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma.
Cancer Res. 61:679-686(2001)

PubMed=11507071
Nino Keshelava, Juan J. Zuo, Ping Chen, Sitara N. Waidyaratne, Marian C. Luna, Charles Joseph Gomer, Timothy J. Triche, Charles Patrick Reynolds;
Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines.
Cancer Res. 61:6185-6193(2001)

PubMed=20922763; DOI=10.1002/pbc.22801; PMCID=PMC3005554
Min H. Kang, Malcolm A. Smith, Christopher L. Morton, Nino Keshelava, Peter J. Houghton, Charles Patrick Reynolds;
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Pediatr. Blood Cancer 56:239-249(2011)

PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959
Mark Sausen, Rebecca J. Leary, Sian Jones, Jian Wu, Charles Patrick Reynolds, Xue-Yuan Liu, Amanda L. Blackford, Giovanni Parmigiani, Luis Alberto Diaz Jr., Nickolas Papadopoulos, Bert Vogelstein ...Show all 14 authors... , Kenneth Wayne Kinzler, Victor E. Velculescu, Michael D. Hogarty; Show fewer authors
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Ahsan S. Farooqi, Rebecca A. Dagg, L. Mi Rim Choi, Jerry W. Shay, Charles Patrick Reynolds, Loretta M.S. Lau;
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

Cross-references
Encyclopedic resources Wikidata; Q54812160
Polymorphism and mutation databases Cosmic; 930053
Cosmic; 1890103
IARC_TP53; 23825
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number20