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Cellosaurus WM278 (CVCL_6473)

[Text version]
Cell line name WM278
Synonyms WM-278; WM 278; WC00054
Accession CVCL_6473
Resource Identification Initiative To cite this cell line use: WM278 (RRID:CVCL_6473)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: Wistar Institute melanoma cell line collection.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (Wistar).
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Hemizygous (Wistar).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=16827748; PubMed=23851445; Cosmic-CLP=1240226; DepMap=ACH-002206; Wistar).
HLA typing Source: PubMed=15592718
Class I
HLA-AA*02:01,26:01
HLA-BB*13:02,38:01
HLA-CC*06:02,12:03
Class II
HLA-DPDPB1*02:01:02,01:01:02
HLA-DQDQB1*06:03,02:01
HLA-DRDRB1*13:01,07:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.85
Native American0
East Asian, North0.99
East Asian, South2.12
South Asian1.13
European, North64.04
European, South30.87
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_6791 ! WM1617
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2809; Cosmic-CLP=1240226; ESTDAB=ESTDAB-077; Wistar

Markers:
AmelogeninX
CSF1PO9
D2S133819,25
D3S135815
D5S81811
D7S8208,10
D8S117912,13
D13S31712
D16S53910,13
D18S5112,15
D19S43315,16
D21S1127,30
FGA19,22
TH016
TPOX8
vWA18,20

Run an STR similarity search on this cell line
Web pages Info; Wistar; -; https://www.wistar.org/our-scientists/meenhard-herlyn
Publications

PubMed=4053039
Meenhard Herlyn, Jan Thurin, Gloria Brady Balaban-Malenbaum, Jeannette L. Bennicelli, Dorothee Herlyn, David E. Elder, Edward Bondi, DuPont Guerry 4th, Peter Carey Nowell, Wallace H. Clark Jr., Hilary Koprowski;
Characteristics of cultured human melanocytes isolated from different stages of tumor progression.
Cancer Res. 45:5670-5676(1985)

PubMed=2253310; DOI=10.1007/BF00046337
Meenhard Herlyn;
Human melanoma: development and progression.
Cancer Metastasis Rev. 9:101-112(1990)

PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966
Teresa Rodriguez, Rosa Mendez, Chrissy H. Roberts, Francisco Ruiz-Cabello Osuna, I. Anthony Dodi, Miguel Angel Lopez-Nevot, Laura Paco, Isabel Maleno, Steven G.E. Marsh, Graham Pawelec, Federico Garrido;
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Keith S. Hoek, Natalie C. Schlegel, Patricia Brafford, Antje Sucker, Selma Ugurel, Rajiv Kumar, Barbara L. Weber, Katherine L. Nathanson, Donald J. Phillips, Meenhard Herlyn, Dirk Schadendorf, Reinhard Dummer;
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235; PMCID=PMC2615688
Keiran S.M. Smalley, Rooha Contractor, Thiennga K. Nguyen, Min Xiao, Robin Edwards, Viswanathan Muthusamy, Alastair J. King, Keith Thomas Flaherty, Marcus W. Bosenberg, Meenhard Herlyn, Katherine L. Nathanson;
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

PubMed=21343389; DOI=10.1158/0008-5472.CAN-10-2958; PMCID=PMC3070783
Amy E. Rose, Laura Poliseno, Jin-Hua Wang, Michael Clark, Alexander Pearlman, Gui-Min Wang, Eleazar Carmelo Vega y Saenz de Miera, Ratna Medicherla, Paul J. Christos, Richard Shapiro, Anna Pavlick ...Show all 17 authors... , Farbod Darvishian, Jiri Zavadil, David Polsky, Eva Hernando, Harry Ostrer, Iman Osman; Show fewer authors
Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.
Cancer Res. 71:2561-2571(2011)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Christina Dahl, Claus Christensen, Goran Jonsson, Anders Lorentzen, Mette Louise Skjodt, Ake Borg, Graham Pawelec, Per Guldberg;
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2809 - Discontinued
Coriell; WC00054 - Discontinued
Rockland; WM278-01-0001
Cell line databases/resources CLO; CLO_0009616
cancercelllines; CVCL_6473
Cell_Model_Passport; SIDM00975
Cosmic-CLP; 1240226
DepMap; ACH-002206
ESTDAB; ESTDAB-077
LINCS_LDP; LCL-1262
Anatomy/cell type resources BTO; BTO_0005480
Biological sample resources BioSample; SAMN03471796
Chemistry resources GDSC; 1240226
PharmacoDB; WM278_1671_2019
Encyclopedic resources Wikidata; Q54994223
Experimental variables resources EFO; EFO_0022559
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM109035
GEO; GSM186479
GEO; GSM186480
GEO; GSM555133
GEO; GSM555172
GEO; GSM1670579
Polymorphism and mutation databases Cosmic; 686401
Cosmic; 972271
Cosmic; 1155544
Cosmic; 1995665
Cosmic; 2159427
Cosmic; 2163805
Progenetix; CVCL_6473
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number41