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Cellosaurus WM1552C (CVCL_6472)

[Text version]

Cell line name WM1552C
Synonyms WM-1552C; WM 1552C; WM-1552; WM1552; EST73
Accession CVCL_6472
Resource Identification Initiative To cite this cell line use: WM1552C (RRID:CVCL_6472)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: Wistar Institute melanoma cell line collection.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in the Cellosaurus and May 2018. The major changes were: D13S317: 12->11,12.
Derived from sampling site: Hypodermis.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=17260012; Wistar).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (Wistar).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=17260012; PubMed=23851445; Cosmic-CLP; DepMap; Wistar).
  • Mutation; HGNC; 9588; PTEN; Simple; c.634+5G>T; Zygosity=Unspecified (PubMed=17260012; PubMed=23851445).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (PubMed=17260012; PubMed=23851445; Cosmic-CLP; DepMap).
HLA typing Source: PubMed=15592718
Class I
HLA-AA*03:01,02:01
HLA-BB*13:02,07:02
HLA-CC*07:02,06:02
Class II
HLA-DPDPB1*04:01,04:02
HLA-DQDQB1*06:02,02:01
HLA-DRDRB1*15:01,ND
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.24
East Asian, North0
East Asian, South1.1
South Asian2.39
European, North72.29
European, South23.98
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; ESTDAB; Wistar

Markers:
AmelogeninX
CSF1PO10
D2S133824,25
D3S135814
D5S81812
D7S82010,11,12 (ATCC)
10,12 (Cosmic-CLP; ESTDAB; Wistar)
D8S117911,12
D13S31711,12 (Wistar)
12 (Cosmic-CLP; ESTDAB)
12,14 (ATCC)
D16S5399,11
D18S5115
D19S43314
D21S1130
FGA22
TH019,9.3
TPOX8,11
vWA19

Run an STR similarity search on this cell line
Web pages https://www.wistar.org/our-scientists/meenhard-herlyn
Publications

PubMed=11123321; DOI=10.4049/jimmunol.166.1.432
Li J., Pereira S., Van Belle P., Tsui P., Elder D., Speicher D., Deen K., Linnenbach A., Somasundaram R., Swoboda R., Herlyn D.
Isolation of the melanoma-associated antigen p23 using antibody phage display.
J. Immunol. 166:432-438(2001)

PubMed=15592718; DOI=10.1007/s00262-004-0561-5
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello F., Dodi I.A., Lopez Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Jonsson G., Dahl C., Staaf J., Sandberg T., Bendahl P.-O., Ringner M., Guldberg P., Borg A.
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

PubMed=19340423; DOI=10.1007/s00262-009-0701-z
Mendez R., Aptsiauri N., Del Campo A., Maleno I., Cabrera T., Ruiz-Cabello F., Garrido F., Garcia-Lora A.
HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.
Cancer Immunol. Immunother. 58:1507-1515(2009)

PubMed=21343389; DOI=10.1158/0008-5472.CAN-10-2958
Rose A.E., Poliseno L., Wang J.-H., Clark M., Pearlman A., Wang G.-M., Vega y Saenz de Miera E.C., Medicherla R., Christos P.J., Shapiro R., Pavlick A., Darvishian F., Zavadil J., Polsky D., Hernando E., Ostrer H., Osman I.
Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.
Cancer Res. 71:2561-2571(2011)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections ATCC; CRL-2808 - Discontinued
Rockland; WM1552C-01-0001
Cell line databases/resources CLO; CLO_0009614
Cell_Model_Passport; SIDM00976
Cosmic-CLP; 1299078
DepMap; ACH-002205
ESTDAB; ESTDAB-073
LINCS_HMS; 50568
LINCS_LDP; LCL-1261
Biological sample resources BioSample; SAMN03471792
Chemistry resources GDSC; 1299078
PharmacoDB; WM1552C_1668_2019
Encyclopedic resources Wikidata; Q54994175
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM156020
GEO; GSM186469
GEO; GSM186470
GEO; GSM555134
GEO; GSM555186
GEO; GSM952582
GEO; GSM1670577
Polymorphism and mutation databases Cosmic; 886833
Cosmic; 1047652
Cosmic; 1303064
Cosmic; 1995664
Cosmic; 2159426
Cosmic; 2163802
IARC_TP53; 26079
Progenetix; CVCL_6472
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update22-Sep-2022
Version number32