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Cellosaurus C8-D1A (CVCL_6379)

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Cell line name C8-D1A
Synonyms C8D1A; Astrocyte type I clone
Accession CVCL_6379
Resource Identification Initiative To cite this cell line use: C8-D1A (RRID:CVCL_6379)
Comments Characteristics: Susceptible to infection by mouse scrapie prion (PrPSc) strains 22L and RML (PubMed=32561641).
Omics: Proteomics.
Omics: Proteomics; Subcellular; Secretome.
Derived from site: In situ; Brain, cerebellum; UBERON=UBERON_0002037.
Cell type: Astrocyte of cerebellum; CL=CL_0002603.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Children:
CVCL_F4WG (HyCyte C8-D1A stable cell line for mApoe overexpression)CVCL_F4QQ (HyCyte C8-D1A stable cell line for mCd38 overexpression)CVCL_F4PY (HyCyte C8-D1A stable cell line for mMmp9 overexpression)
CVCL_F4QR (HyCyte C8-D1A stable cell line for mRhot1 overexpression)
Sex of cell Sex unspecified
Age at sampling 8D
Category Spontaneously immortalized cell line
Publications

PubMed=6466977; DOI=10.1016/0006-8993(84)90377-9
Francoise Alliot, Bernard Pessac;
Astrocytic cell clones derived from established cultures of 8-day postnatal mouse cerebella.
Brain Res. 306:283-291(1984)

PubMed=24753479; DOI=10.1002/pmic.201300495
Do-Hyun Han, Jong-Hwa Jin, Jong-Min Woo, Hophil Min, Youngsoo Kim;
Proteomic analysis of mouse astrocytes and their secretome by a combination of FASP and StageTip-based, high pH, reversed-phase fractionation.
Proteomics 14:1604-1609(2014)

PubMed=26227174; DOI=10.1002/pmic.201400623
Jong-Min Woo, Do-Hyun Han, Joonho Park, Sang Jeong Kim, Youngsoo Kim;
In-depth characterization of the secretome of mouse CNS cell lines by LC-MS/MS without prefractionation.
Proteomics 15:3617-3622(2015)

PubMed=32561641; DOI=10.1074/jbc.RA120.012596; PMCID=PMC7450132
Waqas Tahir, Basant Abdulrahman, Dalia H.A. Abdelaziz, Simrika Thapa, Rupali Walia, Hermann M. Schatzl;
An astrocyte cell line that differentially propagates murine prions.
J. Biol. Chem. 295:11572-11583(2020)

Cross-references
Cell line collections (Providers) ATCC; CRL-2541
CCTCC; GDC0177
CLS; 300316
Hysigen; TCM-C825
Cell line databases/resources CLO; CLO_0002155
CCRID; 4201MOU-CCTCC00177
Encyclopedic resources Wikidata; Q54808244
Proteomic databases PRIDE; PXD000501
PRIDE; PXD001597
Entry history
Entry creation04-Apr-2012
Last entry update25-Jun-2026
Version number15