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Cellosaurus 5637 subclone 1A6 (CVCL_6344)

[Text version]
Cell line name 5637 subclone 1A6
Synonyms 5637 (subclone 1A6); 1A6
Accession CVCL_6344
Resource Identification Initiative To cite this cell line use: 5637 subclone 1A6 (RRID:CVCL_6344)
Comments Group: Patented cell line.
Part of: BLA-40 bladder carcinoma cell line panel.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-556.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; 6871; MAPK1; Simple; p.Arg79Lys (c.236G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Tyr325Ter (c.975T>A); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Thr (c.839G>C); ClinVar=VCV000012368; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0126 (5637)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2742

Markers:
AmelogeninX
CSF1PO11
D5S81811,12
D7S82010,11
D13S31711
D16S5399
TH017,9
TPOX8,9
vWA16,18

Run an STR similarity search on this cell line
Publications

Patent=US6114166
Welte K., Platzer E., Gabrilove J.L., Mertelsmann R., Moore M.A.S.
Human pluripotent hematopoietic colony stimulating factor and cell line producing same.
Patent number US6114166, 05-Sep-2000

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052
Allory Y., Beukers W., Sagrera A., Flandez M., Marques M., Marquez M., van der Keur K.A., Dyrskjot L., Lurkin I., Vermeij M., Carrato A., Lloreta J., Lorente J.A., Carrillo-de-Santa-Pau E., Masius R.G., Kogevinas M., Steyerberg E.W., van Tilborg A.A.G., Abas C., Orntoft T.F., Zuiverloon T.C.M., Malats N., Zwarthoff E.C., Real F.X.
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Eur. Urol. 65:360-366(2014)

PubMed=29732388; DOI=10.3233/BLC-180167
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line collections (Providers) ATCC; CRL-2742 - Discontinued
Cell line databases/resources CLO; CLO_0001149
cancercelllines; CVCL_6344
LINCS_LDP; LCL-1703
Encyclopedic resources Wikidata; Q54582656
Gene expression databases GEO; GSM136246
GEO; GSM827286
GEO; GSM1374374
Polymorphism and mutation databases Cosmic; 2037945
Progenetix; CVCL_6344
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number28