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Cellosaurus RCC63 (CVCL_6266)

[Text version]
Cell line name RCC63
Synonyms RCC10wt63
Accession CVCL_6266
Resource Identification Initiative To cite this cell line use: RCC63 (RRID:CVCL_6266)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:12687; VHL.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Sequence variations
  • Mutation; HGNC; HGNC:12687; VHL; Simple; p.Lys159fs (c.474_477del); Zygosity=Unspecified (PubMed=11114720).
Disease Clear cell renal cell carcinoma (NCIt: C4033)
Clear cell renal carcinoma (ORDO: Orphanet_319276)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6265 (RCC10)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=11114720; DOI=10.1038/sj.onc.1203938
Krieg M., Haas R., Brauch H., Acker T., Flamme I., Plate K.H.
Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
Oncogene 19:5435-5443(2000)

PubMed=15985433; DOI=10.1074/jbc.M500971200
Alberghini A., Recalcati S., Tacchini L., Santambrogio P., Campanella A., Cairo G.
Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells.
J. Biol. Chem. 280:30120-30128(2005)

Cross-references
Encyclopedic resources Wikidata; Q54949470
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number11