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Cellosaurus RCC63 (CVCL_6266)

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Cell line name RCC63
Synonyms RCC10wt63
Accession CVCL_6266
Resource Identification Initiative To cite this cell line use: RCC63 (RRID:CVCL_6266)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:12687; VHL.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Sequence variations
  • Mutation; HGNC; HGNC:12687; VHL; Simple; p.Lys159fs (c.474_477del); Zygosity=Unspecified (PubMed=11114720).
Disease Clear cell renal cell carcinoma (NCIt: C4033)
Clear cell renal carcinoma (ORDO: Orphanet_319276)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6265 (RCC10)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=11114720; DOI=10.1038/sj.onc.1203938
Marion Krieg, Richard Haas, Hiltrud Brauch, Till Acker, Ingo Flamme, Karl Heinz Plate;
Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
Oncogene 19:5435-5443(2000)

PubMed=15985433; DOI=10.1074/jbc.M500971200
Alessandra Alberghini, Stefania Recalcati, Lorenza Tacchini, Paolo Santambrogio, Alessandro Campanella, Gaetano Cairo;
Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells.
J. Biol. Chem. 280:30120-30128(2005)

Cross-references
Encyclopedic resources Wikidata; Q54949470
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number12