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Cellosaurus Akata 2C1 (CVCL_6248)

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Cell line name Akata 2C1
Synonyms 2C1
Accession CVCL_6248
Resource Identification Initiative To cite this cell line use: Akata 2C1 (RRID:CVCL_6248)
Comments Population: Japanese.
Virology: EBV-negative. Treated with hydroxyurea which completely eliminated EBV episomes.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro190Leufs*57 (c.569delC); ClinVar=VCV000825904; Zygosity=Unspecified (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0148 (Akata)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
Publications

PubMed=9593003; DOI=10.1086/515290
James Chodosh, Virgil P. Holder, Yan-Jun Gan, Asim Belgaumi, Jeffery T. Sample, John W. Sixbey;
Eradication of latent Epstein-Barr virus by hydroxyurea alters the growth-transformed cell phenotype.
J. Infect. Dis. 177:1194-1201(1998)

PubMed=10022853; DOI=10.1128/mcb.19.3.1651; PMCID=PMC83959
Ingrid K. Ruf, Paul W. Rhyne, Hui Yang, Corina M. Borza, Lindsey M. Hutt-Fletcher, John L. Cleveland, Jeffery T. Sample;
Epstein-Barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma.
Mol. Cell. Biol. 19:1651-1660(1999)

Cross-references
Encyclopedic resources Wikidata; Q54749084
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number18