Cellosaurus logo
expasy logo

Cellosaurus Akata 2A8 (CVCL_6247)

[Text][XML][JSON]
Cell line name Akata 2A8
Synonyms 2A8
Accession CVCL_6247
Resource Identification Initiative To cite this cell line use: Akata 2A8 (RRID:CVCL_6247)
Comments Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Virology: EBV-negative. Treated with hydroxyurea which completely eliminated EBV episomes.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Proteomics; Expression; Reverse-phase protein array.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro190Leufs*57 (c.569delC); ClinVar=VCV000825904; Zygosity=Unspecified (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0148 (Akata)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=9593003; DOI=10.1086/515290
James Chodosh, Virgil P. Holder, Yan-Jun Gan, Asim Belgaumi, Jeffery T. Sample, John W. Sixbey;
Eradication of latent Epstein-Barr virus by hydroxyurea alters the growth-transformed cell phenotype.
J. Infect. Dis. 177:1194-1201(1998)

PubMed=10022853; DOI=10.1128/mcb.19.3.1651; PMCID=PMC83959
Ingrid K. Ruf, Paul W. Rhyne, Hui Yang, Corina M. Borza, Lindsey M. Hutt-Fletcher, John L. Cleveland, Jeffery T. Sample;
Epstein-Barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma.
Mol. Cell. Biol. 19:1651-1660(1999)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, Agda Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line databases/resources Lonza; 137
Encyclopedic resources Wikidata; Q54749082
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number20