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Cellosaurus A4573 (CVCL_6245)

[Text version]
Cell line name A4573
Synonyms A-4573; ES-A4573
Accession CVCL_6245
Resource Identification Initiative To cite this cell line use: A4573 (RRID:CVCL_6245)
Comments Part of: MD Anderson Cell Lines Project.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Variations; Array-based CGH.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 17Y
Category Cancer cell line
STR profile Source(s): PubMed=30879952

Markers:
AmelogeninX
CSF1PO11,13
D3S135816,17
D5S81811,12
D7S82011
D13S3178,10
D16S53912
FGA24
TH017,8
TPOX8,10
vWA18,19

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=6750238
Paul S. Dickman, Lance Allen Liotta, Timothy J. Triche;
Ewing's sarcoma. Characterization in established cultures and evidence of its histogenesis.
Lab. Invest. 47:375-382(1982)

PubMed=3004699; DOI=10.1016/0165-4608(86)90001-4
Jacqueline Whang-Peng, Timothy J. Triche, Turid Knutsen, James S. Miser, Chien-Song Kao-Shan, Schickwann Tsai, Mark A. Israel;
Cytogenetic characterization of selected small round cell tumors of childhood.
Cancer Genet. Cytogenet. 21:185-208(1986)

PubMed=3390826
Catherine McKeon, Carol Jeanne Thiele, Robert A. Ross, Michael Kwan, Timothy J. Triche, James S. Miser, Mark A. Israel;
Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma.
Cancer Res. 48:4307-4311(1988)

PubMed=2620246; DOI=10.3109/07357908909041371
Subhash C. Gulati, Jong-Hyo Kwon, Jens Atzpodien, Timothy J. Triche, Oliver Michael Colvin, Bayard Delafield Clarkson Sr.;
In vitro chemosensitivity of two Ewing's sarcoma cell lines: implication for autologous bone marrow transplantation.
Cancer Invest. 7:411-416(1989)

DOI=10.1016/B978-0-12-333530-2.50006-X
Mark A. Israel, Carol Jeanne Thiele;
Tumor cell lines of the peripheral nervous system.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

PubMed=21822310; DOI=10.1038/onc.2011.317
Carlos Mackintosh, Jose L. Ordonez, Daniel J. Garcia-Dominguez, Vicky Sevillano, Antonio Llombart-Bosch, Karoly Szuhai, Katia Scotlandi, Marco Alberghini, Raf Sciot, Friedl Sinnaeve, Pancras Cornelis Wilhelmus Hogendoorn ...Show all 17 authors... , Piero Picci, Sakari Knuutila, Uta Dirksen, Maria Debiec-Rychter, Karl-Ludwig Schaefer, Enrique de Alava; Show fewer authors
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.
Oncogene 31:1287-1298(2012)

PubMed=22142829; DOI=10.1158/1078-0432.CCR-11-2056; PMCID=PMC3271129
Neerav Shukla, Nabahet Ameur, Ismail Yilmaz, Khedoudja Nafa, Chyau-Yueh Lau, Angela Marchetti, Laetitia Borsu, Frederic G. Barr, Marc Ladanyi;
Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.
Clin. Cancer Res. 18:748-757(2012)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29464090; DOI=10.18632/oncotarget.23815; PMCID=PMC5814230
Christian Spurny, Sareetha Kailayangiri, Bianca Altvater, Silke Jamitzky, Wolfgang Hartmann, Eva Wardelmann, Andreas Ranft, Uta Dirksen, Susanne Amler, Jendrik Hardes, Maike Fluegge ...Show all 15 authors... , Jutta Meltzer, Nicole Farwick, Lea Greune, Claudia Rossig; Show fewer authors
T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G.
Oncotarget 9:6536-6549(2018)

PubMed=30879952; DOI=10.1016/j.ymthe.2019.02.014; PMCID=PMC6520468
Sareetha Kailayangiri, Bianca Altvater, Stefanie Lesch, Sebastian T. Balbach, Claudia Gottlich, Johanna Kuhnemundt, Jan-Henrik Mikesch, Sonja Schelhaas, Silke Jamitzky, Jutta Meltzer, Nicole Farwick ...Show all 20 authors... , Lea Greune, Maike Fluegge, Kornelius Kerl, Holger N. Lode, Nikolai Siebert, Ingo Muller, Heike Walles, Wolfgang Hartmann, Claudia Rossig; Show fewer authors
EZH2 inhibition in Ewing sarcoma upregulates GD2 expression for targeting with gene-modified T cells.
Mol. Ther. 27:933-946(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6245
Encyclopedic resources Wikidata; Q54606924
Gene expression databases GEO; GSM510001
Polymorphism and mutation databases Cosmic; 1718428
Cosmic; 2060798
Progenetix; CVCL_6245
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22