| Cell line name |
RT112/D21 |
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| Synonyms |
RT-112-D21 |
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| Accession |
CVCL_6215 |
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| Resource Identification Initiative |
To cite this cell line use: RT112/D21 (RRID:CVCL_6215) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255. |
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| Sequence variations |
- Gene fusion; HGNC; HGNC:3690; FGFR3 + HGNC; HGNC:11524; TACC3; Name(s)=FGFR3-TACC3 (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser183Ter (c.548C>G); ClinVar=VCV000634701; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Bladder carcinoma (NCIt: C4912) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1670 (RT-112) |
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| Sex of cell |
Female |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): CLS=300325
Markers:| Amelogenin | X |
| CSF1PO | 10,11 |
| D3S1358 | 15 |
| D5S818 | 10,13 |
| D7S820 | 11,12 |
| D8S1179 | 13,15 |
| D13S317 | 13,14 |
| D16S539 | 11,13 |
| D18S51 | 15 |
| D21S11 | 27,30 |
| FGA | 23 |
| Penta D | 10,11 |
| Penta E | 12,16 |
| TH01 | 7 |
| TPOX | 8,11 |
| vWA | 14,17 |
Run an STR similarity search on this cell line |
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| Publications | PubMed=7740654; DOI=10.1007/BF00296874
Othmar Seemann, Michael Muscheck, Michael J. Siegsmund, Henryk Pilch, Carl Thomas Nebe, Jens Jochen Rassweiler, Peter Alken;
Establishment and characterization of a multidrug-resistant human bladder carcinoma cell line RT112/D21.
Urol. Res. 22:353-360(1995) PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Tahlita C.M. Zuiverloon, Florus C. de Jong, James C. Costello, Dan Theodorescu;
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018) |
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| Cross-references |
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| Cell line collections (Providers) |
CLS; 300325
|
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| Cell line databases/resources |
cancercelllines; CVCL_6215
|
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| Encyclopedic resources |
Wikidata; Q54951357
|
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 22 |
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