Cellosaurus logo
expasy logo

Cellosaurus SK-MEL-186 (CVCL_6096)

[Text version]
Cell line name SK-MEL-186
Synonyms SK-Mel-186; SK-Mel 186; SKMEL-186
Accession CVCL_6096
Resource Identification Initiative To cite this cell line use: SK-MEL-186 (RRID:CVCL_6096)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Sequence variations
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
Publications

PubMed=1716514
Albino A.P., Davis B.M., Nanus D.M.
Induction of growth factor RNA expression in human malignant melanoma: markers of transformation.
Cancer Res. 51:4815-4820(1991)

PubMed=7747814
Gruis N.A., Weaver-Feldhaus J.M., Liu Q.-Y., Frye C., Eeles R., Orlow I., Lacombe L., Ponce-Castaneda V., Lianes P., Latres E., Skolnick M.H., Cordon-Cardo C., Kamb A.
Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression.
Am. J. Pathol. 146:1199-1206(1995)

PubMed=21725359; DOI=10.1038/onc.2011.250
Xing F., Persaud Y., Pratilas C.A., Taylor B.S., Janakiraman M., She Q.-B., Gallardo H., Liu C., Merghoub T., Hefter B., Dolgalev I., Viale A.J., Heguy A., de Stanchina E., Cobrinik D., Bollag G., Wolchok J.D., Houghton A.N., Solit D.B.
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF.
Oncogene 31:446-457(2012)

PubMed=24576830; DOI=10.1158/0008-5472.CAN-13-2625
Nissan M.H., Pratilas C.A., Jones A.M., Ramirez R., Won H., Liu C.-L., Tiwari S., Kong L., Hanrahan A.J., Yao Z., Merghoub T., Ribas A., Chapman P.B., Yaeger R., Taylor B.S., Schultz N., Berger M.F., Rosen N., Solit D.B.
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Cancer Res. 74:2340-2350(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6096
Encyclopedic resources Wikidata; Q54953890
Polymorphism and mutation databases Cosmic; 721813
Cosmic; 923399
Cosmic; 1507614
Cosmic; 1669184
Cosmic; 2233677
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number18