• Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=7747814).
  
• Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=21725359; PubMed=24576830).
  

PubMed=7747814; PMCID=PMC1869278
Nelleke A. Gruis, Jane M. Weaver-Feldhaus, Qing-Yun Liu, Cheryl Frye, Rosalind Eeles, Irene Orlow, Louis Lacombe, Veronica Ponce-Castaneda, Pilar Lianes, Esther Latres, Mark Henry Skolnick ...Show all 13 authors... , Carlos Cordon-Cardo, Alexander Kamb; Show fewer authors
Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression.
Am. J. Pathol. 146:1199-1206(1995)

PubMed=17308088; DOI=10.1158/0008-5472.CAN-06-3311
Janiel M. Shields, Nancy E. Thomas, Melissa Cregger, Aaron J. Berger, Michael Leslie, Chad Torrice, Hong-Lin Hao, Shannon Penland, Jack Leonard Arbiser, Glynis A. Scott, Tong Zhou ...Show all 17 authors... , Menashe Bar-Eli, James E. Bear, Channing Joseph Der, William K. Kaufmann, David Laurence Rimm, Norman Edward Sharpless; Show fewer authors
Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma.
Cancer Res. 67:1502-1512(2007)

PubMed=18505964; DOI=10.1093/jnci/djn157; PMCID=PMC4410798
Daniel E. Freedberg, Sushilaben Harkisandas Rigas, Julie E. Russak, Wei-Ming Gai, Margarita E. Kaplow, Iman Osman, Faye Turner, Juliette A. Randerson-Moor, Alan N. Houghton, Klaus J. Busam, David Timothy Bishop ...Show all 14 authors... , Boris C. Bastian, Julia A. Newton-Bishop, David Polsky; Show fewer authors
Frequent p16-independent inactivation of p14ARF in human melanoma.
J. Natl. Cancer Inst. 100:784-795(2008)

PubMed=21343389; DOI=10.1158/0008-5472.CAN-10-2958; PMCID=PMC3070783
Amy E. Rose, Laura Poliseno, Jin-Hua Wang, Michael Clark, Alexander Pearlman, Gui-Min Wang, Eleazar Carmelo Vega y Saenz de Miera, Ratna Medicherla, Paul J. Christos, Richard Shapiro, Anna Pavlick ...Show all 17 authors... , Farbod Darvishian, Jiri Zavadil, David Polsky, Eva Hernando, Harry Ostrer, Iman Osman; Show fewer authors
Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.
Cancer Res. 71:2561-2571(2011)

PubMed=21725359; DOI=10.1038/onc.2011.250; PMCID=PMC3267014
Feng Xing, Yogindra Persaud, Christine A. Pratilas, Barry Stephen Taylor, Manickam Janakiraman, Qing-Bai She, Humilidad F. Gallardo, Cai-Lian Liu, Taha Merghoub, Blake E. Hefter, Igor Dolgalev ...Show all 19 authors... , Agnes J. Viale, Adriana Heguy, Elisa de Stanchina, David Cobrinik, Gideon Bollag, Jedd David Wolchok, Alan N. Houghton, David B. Solit; Show fewer authors
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF.
Oncogene 31:446-457(2012)

PubMed=24576830; DOI=10.1158/0008-5472.CAN-13-2625; PMCID=PMC4005042
Moriah Heller Nissan, Christine A. Pratilas, Alexis M. Jones, Ricardo Ramirez, Helen Won, Cai-Lian Liu, Shakuntala Tiwari, Li Kong, Aphrothiti J. Hanrahan, Zhan Yao, Taha Merghoub ...Show all 19 authors... , Antoni Ribas, Paul B. Chapman, Rona D. Yaeger, Barry Stephen Taylor, Nikolaus Schultz, Michael F. Berger, Neal Rosen, David B. Solit; Show fewer authors
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Cancer Res. 74:2340-2350(2014)