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Cellosaurus SK-MEL-100 (CVCL_6067)

[Text version]
Cell line name SK-MEL-100
Synonyms SK-Mel-100; SK-MEL 100; SK-Mel 100; SKMEL-100; SKMEL100; DY-Mel
Accession CVCL_6067
Resource Identification Initiative To cite this cell line use: SK-MEL-100 (RRID:CVCL_6067)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Not specified.
Sequence variations
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=6933476; DOI=10.1073/pnas.77.7.4260; PMCID=PMC349812
Alan N. Houghton, Michael C. Taormina, Hisami Ikeda, Tadashi Watanabe, Herbert Friedrich Oettgen, Lloyd John Old;
Serological survey of normal humans for natural antibody to cell surface antigens of melanoma.
Proc. Natl. Acad. Sci. U.S.A. 77:4260-4264(1980)

PubMed=2983346; DOI=10.1073/pnas.82.5.1470; PMCID=PMC397284
Nicholas C. Dracopoli, Alan N. Houghton, Lloyd John Old;
Loss of polymorphic restriction fragments in malignant melanoma: implications for tumor heterogeneity.
Proc. Natl. Acad. Sci. U.S.A. 82:1470-1474(1985)

PubMed=7747814; PMCID=PMC1869278
Nelleke A. Gruis, Jane M. Weaver-Feldhaus, Qing-Yun Liu, Cheryl Frye, Rosalind Eeles, Irene Orlow, Louis Lacombe, Veronica Ponce-Castaneda, Pilar Lianes, Esther Latres, Mark Henry Skolnick ...Show all 13 authors... , Carlos Cordon-Cardo, Alexander Kamb; Show fewer authors
Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression.
Am. J. Pathol. 146:1199-1206(1995)

PubMed=15299072; DOI=10.1158/1535-7163.895.3.8
Jian-Zhong Qin, Lawrence Stennett, Patricia Bacon, Barbara Bodner, Mary J.C. Hendrix, Richard E.B. Seftor, Elisabeth A. Seftor, Naira V. Margaryan, Pamela M. Pollock, Amy Curtis, Jeffrey M. Trent ...Show all 14 authors... , Frank Bennett, Lucio Miele, Brian J. Nickoloff; Show fewer authors
p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas.
Mol. Cancer Ther. 3:895-902(2004)

PubMed=18505964; DOI=10.1093/jnci/djn157; PMCID=PMC4410798
Daniel E. Freedberg, Sushilaben Harkisandas Rigas, Julie E. Russak, Wei-Ming Gai, Margarita E. Kaplow, Iman Osman, Faye Turner, Juliette A. Randerson-Moor, Alan N. Houghton, Klaus J. Busam, David Timothy Bishop ...Show all 14 authors... , Boris C. Bastian, Julia A. Newton-Bishop, David Polsky; Show fewer authors
Frequent p16-independent inactivation of p14ARF in human melanoma.
J. Natl. Cancer Inst. 100:784-795(2008)

PubMed=21343389; DOI=10.1158/0008-5472.CAN-10-2958; PMCID=PMC3070783
Amy E. Rose, Laura Poliseno, Jin-Hua Wang, Michael Clark, Alexander Pearlman, Gui-Min Wang, Eleazar Carmelo Vega y Saenz de Miera, Ratna Medicherla, Paul J. Christos, Richard Shapiro, Anna Pavlick ...Show all 17 authors... , Farbod Darvishian, Jiri Zavadil, David Polsky, Eva Hernando, Harry Ostrer, Iman Osman; Show fewer authors
Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.
Cancer Res. 71:2561-2571(2011)

PubMed=21725359; DOI=10.1038/onc.2011.250; PMCID=PMC3267014
Feng Xing, Yogindra Persaud, Christine A. Pratilas, Barry Stephen Taylor, Manickam Janakiraman, Qing-Bai She, Humilidad F. Gallardo, C. Liu, Taha Merghoub, Blake E. Hefter, Igor Dolgalev ...Show all 19 authors... , Agnes J. Viale, Adriana Heguy, Elisa de Stanchina, David Cobrinik, Gideon Bollag, Jedd D. Wolchok, Alan N. Houghton, David B. Solit; Show fewer authors
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF.
Oncogene 31:446-457(2012)

PubMed=24576830; DOI=10.1158/0008-5472.CAN-13-2625; PMCID=PMC4005042
Moriah Heller Nissan, Christine A. Pratilas, Alexis M. Jones, Ricardo Ramirez, Helen Won, Cai-Lian Liu, Shakuntala Tiwari, Li Kong, Aphrothiti J. Hanrahan, Zhan Yao, Taha Merghoub ...Show all 19 authors... , Antoni Ribas, Paul B. Chapman, Rona D. Yaeger, Barry Stephen Taylor, Nikolaus Schultz, Michael F. Berger, Neal Rosen, David B. Solit; Show fewer authors
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Cancer Res. 74:2340-2350(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6067
Lonza; 1336
Encyclopedic resources Wikidata; Q54953756
Gene expression databases GEO; GSM555126
GEO; GSM555179
GEO; GSM784522
Polymorphism and mutation databases Cosmic; 685206
Cosmic; 721848
Cosmic; 1122257
Cosmic; 1507611
Cosmic; 1669160
Cosmic; 2233670
Cosmic; 2440476
Progenetix; CVCL_6067
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number28