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Cellosaurus MDA-MB-231/B02 (CVCL_5T76)

[Text version]
Cell line name MDA-MB-231/B02
Synonyms MDA-MB-231-B02; MDA-B02; B02
Accession CVCL_5T76
Resource Identification Initiative To cite this cell line use: MDA-MB-231/B02 (RRID:CVCL_5T76)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Omics: Proteomics; Subcellular; Cell surface.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Children:
CVCL_5T77 (B02/GFP.2)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=11697798; DOI=10.1359/jbmr.2001.16.11.2027
Olivier Peyruchaud, Bent Winding, Isabelle Pecheur, Claire-Marie Serre, Pierre Delmas, Philippe Clezardin;
Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions.
J. Bone Miner. Res. 16:2027-2034(2001)

PubMed=18714363; DOI=10.1593/neo.08570; PMCID=PMC2517647
Philippe Kischel, Francois Guillonneau, Bruno Dumont, Akeila Bellahcene, Verena Stresing, Philippe Clezardin, Edwin A. De Pauw, Vincent Castronovo;
Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells.
Neoplasia 10:1014-1020(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5T76
Anatomy/cell type resources BTO; BTO_0004955
Encyclopedic resources Wikidata; Q54904613
Entry history
Entry creation23-Feb-2016
Last entry update10-Apr-2025
Version number21