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Cellosaurus MDA-MB-231/B02 (CVCL_5T76)

[Text version]
Cell line name MDA-MB-231/B02
Synonyms MDA-MB-231-B02; MDA-B02; B02
Accession CVCL_5T76
Resource Identification Initiative To cite this cell line use: MDA-MB-231/B02 (RRID:CVCL_5T76)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Omics: Cell surface proteome.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Children:
CVCL_5T77 (B02/GFP.2)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=11697798; DOI=10.1359/jbmr.2001.16.11.2027
Peyruchaud O., Winding B., Pecheur I., Serre C.-M., Delmas P., Clezardin P.
Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions.
J. Bone Miner. Res. 16:2027-2034(2001)

PubMed=18714363; DOI=10.1593/neo.08570
Kischel P., Guillonneau F., Dumont B., Bellahcene A., Stresing V., Clezardin P., De Pauw E.A., Castronovo V.
Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells.
Neoplasia 10:1014-1020(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5T76
Anatomy/cell type resources BTO; BTO:0004955
Encyclopedic resources Wikidata; Q54904613
Entry history
Entry creation23-Feb-2016
Last entry update05-Oct-2023
Version number19