Cell line name |
MDA-MB-231/B02 |
Synonyms |
MDA-MB-231-B02; MDA-B02; B02 |
Accession |
CVCL_5T76 |
Resource Identification Initiative |
To cite this cell line use: MDA-MB-231/B02 (RRID:CVCL_5T76) |
Comments |
Group: Triple negative breast cancer (TNBC) cell line. Population: Caucasian. Omics: Proteomics; Subcellular; Cell surface. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
|
Disease |
Breast adenocarcinoma (NCIt: C5214) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0062 (MDA-MB-231) Children:
|
Sex of cell |
Female |
Age at sampling |
51Y |
Category |
Cancer cell line |
Publications | PubMed=11697798; DOI=10.1359/jbmr.2001.16.11.2027 Olivier Peyruchaud, Bent Winding, Isabelle Pecheur, Claire-Marie Serre, Pierre Delmas, Philippe Clezardin; Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions. J. Bone Miner. Res. 16:2027-2034(2001) PubMed=18714363; DOI=10.1593/neo.08570; PMCID=PMC2517647 Philippe Kischel, Francois Guillonneau, Bruno Dumont, Akeila Bellahcene, Verena Stresing, Philippe Clezardin, Edwin A. De Pauw, Vincent Castronovo; Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells. Neoplasia 10:1014-1020(2008) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_5T76
|
Anatomy/cell type resources |
BTO; BTO_0004955
|
Encyclopedic resources |
Wikidata; Q54904613
|
Entry history |
Entry creation | 23-Feb-2016 |
Last entry update | 10-Apr-2025 |
Version number | 21 |
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