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Cellosaurus CHME-5 (CVCL_5J53)

[Text version]
Cell line name CHME-5
Synonyms CHME5
Accession CVCL_5J53
Resource Identification Initiative To cite this cell line use: CHME-5 (RRID:CVCL_5J53)
Comments Virology: Supports the replication of M-tropic HIV-1 strain YU-2 (PubMed=17157319).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Miscellaneous: The cell line name was not assigned in the original paper (PubMed=7478261).
Derived from site: In situ; Fetal brain; UBERON=UBERON_0006238.
Cell type: Microglial cell; CL=CL_0000129.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling 8-10FW
Category Transformed cell line
Publications

PubMed=7478261; DOI=10.1016/0304-3940(94)11792-H
Nazila Janabi, Sylviane Peudenier, Benedicte Heron, Kim Heng Ng, Marc Tardieu;
Establishment of human microglial cell lines after transfection of primary cultures of embryonic microglial cells with the SV40 large T antigen.
Neurosci. Lett. 195:105-108(1995)

PubMed=8845742; DOI=10.1016/0197-0186(95)00023-2
Christo L. Atanassov, Christian D. Muller, Serge Dumont, Gerard Rebel, Philippe Poindron, Nikolaus Seiler;
Effect of ammonia on endocytosis and cytokine production by immortalized human microglia and astroglia cells.
Neurochem. Int. 27:417-424(1995)

PubMed=10074188; DOI=10.1128/JVI.73.4.3338-3350.1999; PMCID=PMC104098
Nathalie Arbour, Genevieve Cote, Claude Lachance, Marc Tardieu, Neil R. Cashman, Pierre J. Talbot;
Acute and persistent infection of human neural cell lines by human coronavirus OC43.
J. Virol. 73:3338-3350(1999)

PubMed=17157319; DOI=10.1016/j.jmb.2006.11.011; PMCID=PMC7127718
Pauline Chugh, Shong-Shan Fan, Vicente Planelles, Sanjay B. Maggirwar, Stephen Dewhurst, Baek Kim;
Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.
J. Mol. Biol. 366:67-81(2007)

PubMed=30200996; DOI=10.1186/s12974-018-1288-0; PMCID=PMC6131758
Cinzia Dello Russo, Natalia Cappoli, Isabella Coletta, Daniele Mezzogori, Fabiola Paciello, Giacomo Pozzoli, Pierluigi Navarra, Alessandra Battaglia;
The human microglial HMC3 cell line: where do we stand? A systematic literature review.
J. Neuroinflammation 15:259.1-259.24(2018)

Cross-references
Encyclopedic resources Wikidata; Q54812518
Entry history
Entry creation14-Dec-2015
Last entry update14-Aug-2025
Version number18