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Cellosaurus TH1 (CVCL_5J51)

[Text version]
Cell line name TH1
Accession CVCL_5J51
Resource Identification Initiative To cite this cell line use: TH1 (RRID:CVCL_5J51)
Comments Group: Patented cell line.
Characteristics: Reversible immortalized. The transfected hTERT and SV40 Tag genes are flanked by loxP sites. Transient Cre expression in this cell line leads to deletion of the two genes thus leading to a decrease in the rate of cell proliferation and ultimately to cell senescence.
Doubling time: 40-48 hours (PubMed=15208689).
Transfected with: HGNC; 11730; TERT.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5J52 ! TH7
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=15208689; DOI=10.1038/sj.onc.1207801
Kowolik C.M., Liang S., Yu Y., Yee J.-K.
Cre-mediated reversible immortalization of human renal proximal tubular epithelial cells.
Oncogene 23:5950-5957(2004)

Patent=US20050136539
Kowolik C.M., Yee J.-K.
Reversible immortalization of human renal proximal tubular epithelial cells.
Patent number US20050136539, 23-Jun-2005

Cross-references
Cell line collections (Providers) Kerafast; ECH001
Encyclopedic resources Wikidata; Q54972283
Entry history
Entry creation14-Dec-2015
Last entry update29-Jun-2023
Version number11