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Cellosaurus eHAP A11 (CVCL_5J32)

[Text version]
Cell line name eHAP A11
Synonyms eHAPA11; Engineered-HAPloid clone A11
Accession CVCL_5J32
Resource Identification Initiative To cite this cell line use: eHAP A11 (RRID:CVCL_5J32)
Comments Group: Haploid karyotype cell line.
Omics: Genome sequenced.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Y019 (HAP1)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Publications

PubMed=25373145; DOI=10.1101/gr.177220.114
Essletzbichler P., Konopka T., Santoro F., Chen D., Gapp B.V., Kralovics R., Brummelkamp T.R., Nijman S.M.B., Burckstummer T.
Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.
Genome Res. 24:2059-2065(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5J32
Encyclopedic resources Wikidata; Q54832106
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number11