Cellosaurus cell line NCI-H460-luc2 (CVCL

Cross-references
Cell line name	NCI-H460-luc2
Accession	CVCL_5J23
Resource Identification Initiative	To cite this cell line use: NCI-H460-luc2 (RRID:CVCL_5J23)
Comments	Population: Caucasian. Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase (Note=With optimized codon usage for mammalian expression = Luc2). Discontinued: Revvity/PerkinElmer; 124316; true. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease	Lung large cell carcinoma (NCIt: C4450)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0459 (NCI-H460)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Cancer cell line
Cell line collections (Providers)	Revvity/PerkinElmer; 124316
Cell line databases/resources	cancercelllines; CVCL_5J23
Encyclopedic resources	Wikidata; Q54908061
Entry history
Entry creation	14-Dec-2015
Last entry update	14-Aug-2025
Version number	14