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Cellosaurus MCF-7/VP (CVCL_5I65)

[Text version]
Cell line name MCF-7/VP
Synonyms MCF7-VP; MCF7/VP; MCF-7 VP-16; MCF-7/VP16; MCF7-VP16
Accession CVCL_5I65
Resource Identification Initiative To cite this cell line use: MCF-7/VP (RRID:CVCL_5I65)
Comments Population: Caucasian.
Doubling time: 47 hours (PubMed=8562478).
Selected for resistance to: ChEBI; CHEBI_4911; Etoposide (VP-16).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=7903202
Erasmus Schneider, Julie K. Horton, Chih-Hsin Yang, Masayuki Nakagawa, Kenneth H. Cowan;
Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance.
Cancer Res. 54:152-158(1994)

PubMed=8562478
Katja Wosikowski, Joanna T. Regis, Robert W. Robey, Manuel Alvarez, Jeroen Titus Maria Buters, Jean Marie Gudas, Susan E. Bates;
Normal p53 status and function despite the development of drug resistance in human breast cancer cells.
Cell Growth Differ. 6:1395-1403(1995)

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robert W. Robey, Yasumasa Honjo, Anne van de Laar, Keisuke Miyake, Joanna T. Regis, Thomas Litman, Susan E. Bates;
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5I65
Chemistry resources ChEMBL-Cells; CHEMBL3307299
ChEMBL-Targets; CHEMBL614128
ChEMBL-Targets; CHEMBL614329
PubChem_Cell_line; CVCL_5I65
Encyclopedic resources Wikidata; Q54904398
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number15