| Cell line name |
MCF-7 FLV1000 |
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| Synonyms |
MCF-7-FLV1000; MCF-7/Flv1000; MCF7-FLV1000; MCF-7FL-1000; MCF-7-FL1000; MCF-7 FL1000; MCF7FL1000; MCF FLV1000 |
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| Accession |
CVCL_5I64 |
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| Resource Identification Initiative |
To cite this cell line use: MCF-7 FLV1000 (RRID:CVCL_5I64) |
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| Comments |
Population: Caucasian.
Characteristics: Resistant to 1000 nM of flavopiridol (PubMed=11205902).
Selected for resistance to: ChEBI; CHEBI_47344; Alvocidib (Flavopiridol; HMR-1275).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0031 (MCF-7) |
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| Sex of cell |
Female |
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| Age at sampling |
69Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=11205902
Robert W. Robey, Wilma Y. Medina-Perez, Kenryu Nishiyama, Tyler Lahusen, Keisuke Miyake, Thomas Litman, Adrian M. Senderowicz, Douglas D. Ross, Susan E. Bates;
Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.
Clin. Cancer Res. 7:145-152(2001) PubMed=11559526
Yasumasa Honjo, Christine A. Hrycyna, Qing-Wu Yan, Wilma Y. Medina-Perez, Robert W. Robey, Anne van de Laar, Thomas Litman, Michael Dean, Susan E. Bates;
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001) PubMed=12642696; DOI=10.4161/cbt.322
Yasumasa Honjo, Kuniaki Morisaki, Lyn Mickley Huff, Robert W. Robey, Jeffrey Hung, Michael Dean, Susan E. Bates;
Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).
Cancer Biol. Ther. 1:696-702(2002) |
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| Cross-references |
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| Cell line collections (Providers) |
ABM; T8035
|
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| Cell line databases/resources |
cancercelllines; CVCL_5I64
|
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| Encyclopedic resources |
Wikidata; Q54904332
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| Entry history |
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| Entry creation | 14-Dec-2015 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 16 |
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