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Cellosaurus MDA231-LM2-4175 (CVCL_5998)

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Cell line name MDA231-LM2-4175
Synonyms MDA231-LM2; MDA 231-LM2-4175; MDA-MB-231 #4175; LM2-4175; 4175
Accession CVCL_5998
Resource Identification Initiative To cite this cell line use: MDA231-LM2-4175 (RRID:CVCL_5998)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Established from MDA231-TGL cell line after 3 passage in nude mice.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Omics: Proteomics; 2DE.
Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VR35 (MDA231-TGL)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): MSKCC

Markers:
AmelogeninX
CSF1PO12,13
D1S165615,17
D2S44114,15
D2S133820,21
D3S135816
D5S81812
D7S8208
D8S117913
D10S124816
D12S39117,18
D13S31713
D16S53912
D18S5111,16
D19S43311,14
D21S1133.2
D22S104515,16,17
FGA22,23
Penta D14
Penta E11
TH017,9.3
TPOX8,9
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=16049480; DOI=10.1038/nature03799; PMCID=PMC1283098
Andy J. Minn, Gaorav P. Gupta, Peter M. Siegel, Paula D. Bos, Wei-Ping Shu, Dilip D. Giri, Agnes J. Viale, Adam B. Olshen, William Levi Gerald, Joan Massague;
Genes that mediate breast cancer metastasis to lung.
Nature 436:518-524(2005)

PubMed=18425382; DOI=10.3892/or.19.5.1237
Irena Selicharova, Miloslav Sanda, Jana Mladkova, Sujata Saraswat Ohri, Aruna Vashishta, Martin Fusek, Jiri Jiracek, Vaclav Vetvicka;
2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: comparison with parental cell line MDA-MB-231.
Oncol. Rep. 19:1237-1244(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5998
Chemistry resources ChEMBL-Cells; CHEMBL4879540
Encyclopedic resources Wikidata; Q54904666
Gene expression databases GEO; GSM49956
GEO; GSM587391
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number29