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Cellosaurus JHU-019 (CVCL_5989)

[Text version]
Cell line name JHU-019
Synonyms JHU 019; JHU-O19; JHU019; O19; 019; 19; Johns Hopkins University-019
Accession CVCL_5989
Resource Identification Initiative To cite this cell line use: JHU-019 (RRID:CVCL_5989)
Comments Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=21868764). Originally thought to originate from a 58 year old female patient with oropharyngeal squamous cell carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00405.
Population: Caucasian.
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=21868764

D5S8189,13 (ATCC)
13 (PubMed=21868764)

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

PubMed=12925955; DOI=10.1002/ijc.11341
Minhas K.M., Singh B., Jiang W.-W., Sidransky D., Califano J.A. III
Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma.
Int. J. Cancer 107:46-52(2003)

PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6
Hoque M.O., Begum S., Sommer M., Lee T., Trink B., Ratovitski E., Sidransky D.
PUMA in head and neck cancer.
Cancer Lett. 199:75-81(2003)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

Cell line collections (Providers) ATCC; CRL-2721 - Discontinued
Cell line databases/resources cancercelllines; CVCL_5989
Anatomy/cell type resources BTO; BTO:0003889
Biological sample resources BioSample; SAMN03151893
BioSample; SAMN03471776
Chemistry resources PharmacoDB; JHU019_694_2019
Encyclopedic resources Wikidata; Q54898670
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number24