Cellosaurus logo
expasy logo

Cellosaurus JHU-019 (CVCL_5989)

[Text][XML][JSON]
Cell line name JHU-019
Synonyms JHU 019; JHU-O19; JHU019; O19; 019; 19; Johns Hopkins University-019
Accession CVCL_5989
Resource Identification Initiative To cite this cell line use: JHU-019 (RRID:CVCL_5989)
Comments Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=21868764). Originally thought to originate from a 58 year old female patient with oropharyngeal squamous cell carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00405.
Population: Caucasian.
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2721; PubMed=21868764

Markers:
AmelogeninX
CSF1PO11
D5S8189,13 (ATCC=CRL-2721)
13 (PubMed=21868764)
D7S8208,11
D13S31711
D16S53911
TH016,7
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=12925955; DOI=10.1002/ijc.11341
Khalid M. Minhas, Bhuvanesh Singh, Wei-Wen Jiang, David Sidransky, Joseph A. Califano 3rd;
Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma.
Int. J. Cancer 107:46-52(2003)

PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6
Mohammad Obaidul Hoque, Shahnaz Begum, Matthias Sommer, Taekyeol Lee, Barry Trink, Edward Ratovitski, David Sidransky;
PUMA in head and neck cancer.
Cancer Lett. 199:75-81(2003)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

Cross-references
Cell line collections (Providers) ATCC; CRL-2721 - Discontinued
Cell line databases/resources cancercelllines; CVCL_5989
Anatomy/cell type resources BTO; BTO_0003889
Biological sample resources BioSample; SAMN03151893
BioSample; SAMN03471776
Chemistry resources PharmacoDB; JHU019_694_2019
Encyclopedic resources Wikidata; Q54898670
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27