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Cellosaurus C-643 (CVCL_5969)

[Text version]
Cell line name C-643
Synonyms C 643; C643; c643
Accession CVCL_5969
Resource Identification Initiative To cite this cell line use: C-643 (RRID:CVCL_5969)
Comments Doubling time: 23 hours (PubMed=31368081).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
Disease Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 76Y
Category Cancer cell line
STR profile Source(s): CLS=300298; PubMed=17465858; PubMed=18713817; PubMed=21868764; PubMed=25365311; PubMed=30737244; PubMed=31368081

Markers:
AmelogeninX,Y
CSF1PO10,11
D3S135815
D5S81811,12
D7S8209,12
D8S117911,13
D13S3178,10
D16S5399,13
D18S5114 (PubMed=31368081)
14,17 (PubMed=17465858)
14,18 (CLS=300298; PubMed=18713817; PubMed=30737244)
D21S1128
FGA18,21
Penta D9
Penta E5,15
TH019.3,10
TPOX11,12
vWA15,17

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Publications

PubMed=2848260; DOI=10.1073/pnas.85.23.9302; PMCID=PMC282727
Nils-Erik Heldin, Bengt Gustavsson, Lena Claesson-Welsh, Annet Hammacher, Joachim Mark, Carl-Henrik Heldin, Bengt Westermark;
Aberrant expression of receptors for platelet-derived growth factor in an anaplastic thyroid carcinoma cell line.
Proc. Natl. Acad. Sci. U.S.A. 85:9302-9306(1988)

PubMed=14522906
Francesco Frasca, Veronica Vella, Alessandra Aloisi, Angelo Mandarino, Emanuela Mazzon, Riccardo Vigneri, Paolo Vigneri;
p73 tumor-suppressor activity is impaired in human thyroid cancer.
Cancer Res. 63:5829-5837(2003)

PubMed=17465858; DOI=10.1089/thy.2006.0246
Jia-Jing Lee, Theodoros Foukakis, Jamileh Hashemi, Lars Grimelius, Nils-Erik Heldin, Goran Wallin, Christina Rudduck, Weng-Onn Lui, Anders Hoog, Catharina Larsson;
Molecular cytogenetic profiles of novel and established human anaplastic thyroid carcinoma models.
Thyroid 17:289-301(2007)

PubMed=17725429; DOI=10.1089/thy.2007.0097
Ana Margarida Meireles, Ana Preto, Ana Sofia Rocha, Ana Paula Rebocho, Valdemar Maximo, Isabel Pereira-Castro, Severina Moreira, Talia Feijao, Tiago Botelho, Ricardo Marques, Vitor Trovisco ...Show all 16 authors... , Luis Cirnes, Cintia Alves, Sergia Velho, Paula Soares, Manuel Sobrinho-Simoes; Show fewer authors
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.
Thyroid 17:707-715(2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569
Rebecca E. Schweppe, Joshua P. Klopper, Christopher T. Korch, Umarani Pugazhenthi, Miriam Benezra, Jeffrey A. Knauf, James Alexander Fagin, Laura A. Marlow, John Alton Copland 3rd, Robert Christian Smallridge, Bryan R. Haugen;
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=19087340; DOI=10.1186/1471-2407-8-371; PMCID=PMC2651892
Franclim Ricardo Ribeiro, Ana Margarida Meireles, Ana Sofia Rocha, Manuel R. Teixeira;
Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples.
BMC Cancer 8:371.1-371.11(2008)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971
Inigo Landa, Ian Ganly, Timothy A. Chan, Norisato Mitsutake, Michiko Matsuse, Tihana Ibrahimpasic, Ronald A. Ghossein, James Alexander Fagin;
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=25365311; DOI=10.1210/jc.2014-2359; PMCID=PMC4318896
Manoj Garg, Ryoko Okamoto, Yasunobu Nagata, Deepika Kanojia, Subhashree Venkatesan, Mayakonda Thippeswamy Anand, Glenn D. Braunstein, Jonathan William Said, Ngan B. Doan, Quoc Ho, Tadayuki Akagi ...Show all 18 authors... , Sigal Gery, Li-Zhen Liu, Kar-Tong Tan, Wee Joo Chang, Henry He Yang, Seishi Ogawa, Harold Phillip Koeffler; Show fewer authors
Establishment and characterization of novel human primary and metastatic anaplastic thyroid cancer cell lines and their genomic evolution over a year as a primagraft.
J. Clin. Endocrinol. Metab. 100:725-735(2015)

PubMed=26680454; DOI=10.1186/s12885-015-1955-9; PMCID=PMC4683857
Katayoon Kasaian, Sam M. Wiseman, Blair A. Walker, Jacqueline E. Schein, Yong-Jun Zhao, Martin Hirst, Richard A. Moore, Andrew J. Mungall, Marco Antonio Marra, Steven J.M. Jones;
The genomic and transcriptomic landscape of anaplastic thyroid cancer: implications for therapy.
BMC Cancer 15:984.1-984.11(2015)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=31368081; DOI=10.1007/s12020-019-02009-5
Ana T. Pinto, Marta Pojo, Joana Simoes-Pereira, Ruben Roque, Ana Saramago, Lucia Roque, Carmo Martins, Saudade Andre, Jose Cabecadas, Valeriano Leite, Branca M. Cavaco;
Establishment and characterization of a new patient-derived anaplastic thyroid cancer cell line (C3948), obtained through fine-needle aspiration cytology.
Endocrine 66:288-300(2019)

Cross-references
Cell line collections (Providers) CLS; 300298
IBRC; C10312
Cell line databases/resources cancercelllines; CVCL_5969
CCRID; 3101HUMSCSP545
Anatomy/cell type resources BTO; BTO_0005149
Encyclopedic resources Wikidata; Q54799751
Polymorphism and mutation databases Cosmic; 888095
Cosmic; 888279
Cosmic; 889491
Cosmic; 913251
Cosmic; 1068625
Cosmic; 1084282
Cosmic; 1152117
Cosmic; 1155331
Cosmic; 1239971
Cosmic; 1280042
Cosmic; 1507379
Cosmic; 1533557
Cosmic; 1536132
Cosmic; 1889012
Cosmic; 2036693
Cosmic; 2054091
Cosmic; 2186783
Cosmic; 2319850
Cosmic; 2786688
Cosmic; 2791079
IARC_TP53; 21626
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number32