Cellosaurus logo
expasy logo

Cellosaurus IOMM-Lee (CVCL_5779)

[Text version]
Cell line name IOMM-Lee
Synonyms IOMM-LEE; Iomm-Lee; IOMM Lee; IOMMLEE; IntraOsseous Malignant Meningioma-Lee
Accession CVCL_5779
Resource Identification Initiative To cite this cell line use: IOMM-Lee (RRID:CVCL_5779)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Chinese.
Doubling time: ~62 hours (PubMed=2234331); 18 hours (PubMed=25984343); 0.8 day (PubMed=34850056); ~22 hours (ATCC=CRL-3370).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; shRNA library screening.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (DepMap=ACH-000629).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=28552950).
Disease Intracranial meningioma (NCIt: C4656)
Meningioma (ORDO: Orphanet_2495)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_HA67 (IOMM-Lee-LucNeo)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3370

Markers:
AmelogeninX
CSF1PO9,10
D5S81811,13
D7S82011,12
D13S3178,9
D16S53912,13
TH016,7
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=2234331; DOI=10.1097/00006123-199009000-00008
Wei-Hwa Lee;
Characterization of a newly established malignant meningioma cell line of the human brain: IOMM-Lee.
Neurosurgery 27:389-396(1990)

PubMed=16554968; DOI=10.1007/s11060-005-9076-y
Gilson S. Baia, Alison L. Slocum, Jeanette D. Hyer, Anjan Misra, Nouzhan Sehati, Scott R. VandenBerg, Burt Gary Feuerstein, Dennis F. Deen, Michael W. McDermott, Anita Lal;
A genetic strategy to overcome the senescence of primary meningioma cell cultures.
J. Neurooncol. 78:113-121(2006)

PubMed=18261772; DOI=10.1016/j.surneu.2007.06.031
Brian Thomas Ragel, William Tupper Couldwell, David L. Gillespie, Merideth Michele Wendland, Kum Whang, Randy Lynn Jensen;
A comparison of the cell lines used in meningioma research.
Surg. Neurol. 70:295-307(2008)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=28552950; DOI=10.1371/journal.pone.0178322; PMCID=PMC5446134
Yu Mei, Wen-Ya Linda Bi, Noah F. Greenwald, Nathalie Yvonne Rachel Agar, Rameen Beroukhim, Gavin P. Dunn, Ian F. Dunn;
Genomic profile of human meningioma cell lines.
PLoS ONE 12:e0178322.1-e0178322.12(2017)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=34850056; DOI=10.1093/jnen/nlab111; PMCID=PMC8716066
Erik Janos Uhlmann, Rosalia Rabinovsky, Hemant Varma, Rachid El Fatimy, Ekkehard M. Kasper, Justin M. Moore, Rafael A. Vega, Ajith J. Thomas, Ronald L. Alterman, Martina Stippler, Matthew P. Anderson ...Show all 14 authors... , Erik N. Uhlmann, Franciele Cristina Kipper, Anna M. Krichevsky; Show fewer authors
Tumor-derived cell culture model for the investigation of meningioma biology.
J. Neuropathol. Exp. Neurol. 80:1117-1124(2021)

Cross-references
Cell line collections (Providers) ATCC; CRL-3370
Cell line databases/resources cancercelllines; CVCL_5779
Cell_Model_Passport; SIDM01733
DepMap; ACH-000629
Anatomy/cell type resources BTO; BTO_0004464
Biological sample resources BioSample; SAMN10988414
Chemistry resources PharmacoDB; IOMMLee_661_2019
Encyclopedic resources Wikidata; Q54897853
Polymorphism and mutation databases Cosmic; 2516047
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22