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Cellosaurus H-MESO-1 (CVCL_5759)

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Cell line name H-MESO-1
Synonyms H-Meso-1; HMESO-1; HMeso-1; HMeso1; HMESO1; H-Meso; HMESO; HMeso; Hmeso; MM-E1
Accession CVCL_5759
Resource Identification Initiative To cite this cell line use: H-MESO-1 (RRID:CVCL_5759)
Comments Transformant: ChEBI; CHEBI_46661; Asbestos.
Omics: Variations; SNP array analysis.
Caution: Indicated as originating from a 35 year old male patient in PubMed=3555770 and from a 42 year old male patient in PubMed=3496960.
Caution: It seems that PubMed=10373640 has renamed this cell line as MM-E1 because they thought it has a have an epithelial morphology.
Derived from site: In situ; Lung, pleura; UBERON=UBERON_0000977.
Sequence variations
Disease Pleural biphasic mesothelioma (NCIt: C45665)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5760 (H-MESO-1A)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
STR profile Source(s): CLS=300186

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135814
D5S81810,12
D7S82012
D8S117910
D13S31711
D16S53912
D18S5114,20
D21S1130,33.2
FGA23
Penta D11,13
Penta E7,11
TH016,9.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=3496960
Thomas W. Griffin, Carol Richardson, Lou L. Houston, Doreen LePage, Arthur Bogden, Victor A. Raso;
Antitumor activity of intraperitoneal immunotoxins in a nude mouse model of human malignant mesothelioma.
Cancer Res. 47:4266-4270(1987)

PubMed=3555770
Frank R. Reale, Thomas W. Griffin, Joyce M. Compton, Suzanne Graham, Philip Leonard Townes, Arthur Bogden;
Characterization of a human malignant mesothelioma cell line (H-MESO-1): a biphasic solid and ascitic tumor model.
Cancer Res. 47:3199-3205(1987)

PubMed=10373640; DOI=10.3892/ijmm.4.1.67
Susanna Scarpa, Anna Giuffrida, Massimina Fazi, Anna Coletti, Camilla Palumbo, Harvey I. Pass, Antonio Procopio, Andrea Modesti;
Migration of mesothelioma cells correlates with histotype-specific synthesis of extracellular matrix.
Int. J. Mol. Med. 4:67-71(1999)

PubMed=21454801; DOI=10.1165/rcmb.2010-0282OC; PMCID=PMC3262687
Arti Shukla, Trisha F. Barrett, Maximilian B. MacPherson, Jedd Michael Hillegass, Naomi Kay Fukagawa, William A. Swain, Kenneth J. O'Byrne, Joseph R. Testa, Harvey I. Pass, Stephen P. Faux, Brooke Taylor Mossman;
An extracellular signal-regulated kinase 2 survival pathway mediates resistance of human mesothelioma cells to asbestos-induced injury.
Am. J. Respir. Cell Mol. Biol. 45:906-914(2011)

PubMed=21642991; DOI=10.1038/ng.855; PMCID=PMC4643098
Matthew J. Bott, Marie Brevet, Barry Stephen Taylor, Shigeki Shimizu, Tatsuo Ito, Lu Wang, Jenette Creaney, Richard A. Lake, Maureen F. Zakowski, Boris A. Reva, Chris Sander ...Show all 18 authors... , Robert Delsite, Simon N. Powell, Qin Zhou, Rong-Lai Shen, Adam B. Olshen, Valerie W. Rusch, Marc Ladanyi; Show fewer authors
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
Nat. Genet. 43:668-672(2011)

PubMed=28159921; DOI=10.18632/oncotarget.14907; PMCID=PMC5470978
Laura Masuelli, Monica Benvenuto, Enrica Di Stefano, Rosanna Mattera, Massimo Fantini, Giuseppina De Feudis, Enrico De Smaele, Ilaria Tresoldi, Maria Gabriella Giganti, Andrea Modesti, Roberto Bei;
Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line.
Oncotarget 8:34405-34422(2017)

Cross-references
Cell line collections (Providers) CLS; 300186
NCI-DTP; H-MESO-1
Cell line databases/resources cancercelllines; CVCL_5759
Anatomy/cell type resources BTO; BTO_0005907
Biological sample resources BioSamples; SAMEA100968
Encyclopedic resources Wikidata; Q54871890
Gene expression databases GEO; GSM726268
Polymorphism and mutation databases Cosmic; 922059
Cosmic; 1522785
Cosmic; 1541215
Progenetix; CVCL_5759
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27