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Cellosaurus DU528 (CVCL_5617)

[Text version]
Cell line name DU528
Synonyms DU-528; Du-528; DU.528; Duke University 528
Accession CVCL_5617
Resource Identification Initiative To cite this cell line use: DU528 (RRID:CVCL_5617)
Comments Doubling time: 48-72 hours (PubMed=4056659); 40 hours (PubMed=17117183).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=2144611).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 16Y
Category Cancer cell line
Web pages https://humantallcelllines.wordpress.com/comprehensivetable/du-528/

PubMed=4056659; DOI=10.1084/jem.162.5.1561
Kurtzberg J., Bigner S.H., Hershfield M.S.
Establishment of the DU.528 human lymphohemopoietic stem cell line.
J. Exp. Med. 162:1561-1578(1985)

PubMed=2740341; DOI=10.1073/pnas.86.13.5039
Finger L.R., Kagan J., Christopher G., Kurtzberg J., Hershfield M.S., Nowell P.C., Croce C.M.
Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.
Proc. Natl. Acad. Sci. U.S.A. 86:5039-5043(1989)

PubMed=2144611; DOI=10.1128/mcb.10.10.5502-5509.1990
Cheng J., Haas M.
Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.
Mol. Cell. Biol. 10:5502-5509(1990)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15472075; DOI=10.1126/science.1102160
Weng A.P., Ferrando A.A., Lee W., Morris J.P. IV, Silverman L.B., Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=17117183; DOI=10.1038/sj.bjc.6603447
Beesley A.H., Palmer M.-L., Ford J., Weller R.E., Cummings A.J., Freitas J.R., Firth M.J., Perera K.U., de Klerk N.H., Kees U.R.
Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines.
Br. J. Cancer 95:1537-1544(2006)

PubMed=17170727; DOI=10.1038/sj.leu.2404486
Sandberg Y., Verhaaf B., van Gastel-Mol E.J., Wolvers-Tettero I.L.M., de Vos J., MacLeod R.A.F., Noordzij J.G., Dik W.A., van Dongen J.J.M., Langerak A.W.
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Leukemia 21:230-237(2007)

Encyclopedic resources Wikidata; Q54831579
Polymorphism and mutation databases Cosmic; 913423
Cosmic; 1115590
Cosmic; 1151778
Cosmic; 1281367
Cosmic; 2602913
IARC_TP53; 21651
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number17