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Cellosaurus IOSE-80 (CVCL_5546)

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Cell line name IOSE-80
Synonyms IOSE 80; IOSE80; NFHIOSE-80; IOSE80UBC; IOSE-Van; IOSE-VAN
Accession CVCL_5546
Resource Identification Initiative To cite this cell line use: IOSE-80 (RRID:CVCL_5546)
Comments From: Canadian Ovarian Tissue Bank, University of British Columbia; Vancouver; Canada.
Doubling time: 26.2 hours (PubMed=10329039).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Ovary, surface epithelium; UBERON=UBERON_0001304.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5547 (IOSE-80PC)CVCL_5548 (IOSE-80RZ)CVCL_2G68 (T80)
Sex of cell Female
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=1326894; DOI=10.1016/S0002-9378(11)91579-8
Sarah L. Maines-Bandiera, Patricia A. Kruk, Nelly Auersperg;
Simian virus 40-transformed human ovarian surface epithelial cells escape normal growth controls but retain morphogenetic responses to extracellular matrix.
Am. J. Obstet. Gynecol. 167:729-735(1992)

PubMed=7967506
Nelly Auersperg, Sarah L. Maines-Bandiera, Helen G. Dyck, Patricia A. Kruk;
Characterization of cultured human ovarian surface epithelial cells: phenotypic plasticity and premalignant changes.
Lab. Invest. 71:510-518(1994)

PubMed=10329039; DOI=10.1006/gyno.1999.5348
Patricia A. Kruk, Andrew Kent Godwin, Thomas C. Hamilton, Nelly Auersperg;
Telomeric instability and reduced proliferative potential in ovarian surface epithelial cells from women with a family history of ovarian cancer.
Gynecol. Oncol. 73:229-236(1999)

DOI=10.5282/edoc.3898
Nicole Isabel Euer;
Identification of target genes for the therapy and diagnosis of ovarian carcinoma.
Thesis PhD (2005); Ludwig Maximilians University of Munich; Munich; Germany

PubMed=15706405; DOI=10.3892/or.13.3.375
Nicole Isabel Euer, Sepp Kaul, Helmut Deissler, Volker J. Mobus, Robert Zeillinger, Ulrich H. Weidle;
Identification of L1CAM, Jagged2 and neuromedin U as ovarian cancer-associated antigens.
Oncol. Rep. 13:375-387(2005)

PubMed=15947112; DOI=10.1677/erc.1.00896
Jung-Hye Choi, Kyung-Chul Choi, Nelly Auersperg, Peter C.K. Leung;
Gonadotropins upregulate the epidermal growth factor receptor through activation of mitogen-activated protein kinases and phosphatidyl-inositol-3-kinase in human ovarian surface epithelial cells.
Endocr. Relat. Cancer 12:407-421(2005)

PubMed=19926575; DOI=10.1309/AJCPTK87EMMIKPFS; PMCID=PMC3040237
Melissa S. DeRycke, John D. Andersen, Katherine M. Harrington, Stefan Eduard Pambuccian, Steve E. Kalloger, Kristin L.M. Boylan, Peter Alexander Argenta, Amy Patrice Norden Skubitz;
S100A1 expression in ovarian and endometrial endometrioid carcinomas is a prognostic indicator of relapse-free survival.
Am. J. Clin. Pathol. 132:846-856(2009)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023
Britta Stordal, Kirsten Timms, Angela Farrelly, Danielle Gallagher, Steven Busschots, Mickael Renaud, Julien Thery, Deborah Williams, Jennifer Potter, Thanh Tran, Greg Korpanty ...Show all 19 authors... , Mattia Cremona, Mark S. Carey, Jie Li, Yang Li, Ozlem Aslan, John J. O'Leary, Gordon B. Mills, Bryan T. Hennessy; Show fewer authors
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

Cross-references
Cell line databases/resources Lonza; 13
Encyclopedic resources Wikidata; Q54897904
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number20