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Cellosaurus HTOA (CVCL_5457)

[Text version]
Cell line name HTOA
Accession CVCL_5457
Resource Identification Initiative To cite this cell line use: HTOA (RRID:CVCL_5457)
Comments Population: Japanese.
Doubling time: 74.5 hours (Note=At 5th passage), 68.2 hours (Note=At 25th passage), 72 hours (Note=At 50th passage) (PubMed=2435620); 70 hours (PubMed=3593088).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): RCB=RCB0692

Markers:
AmelogeninX
CSF1PO12,13
D5S81811,13
D7S8209,10
D13S3178,10
D16S5399,13
TH017
TPOX11
vWA17

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Publications

PubMed=2429643; DOI=10.1111/j.1447-0756.1986.tb00192.x
Ishiwata I., Ishiwata C., Nozawa S., Ishikawa H.
CA125 production by gynecologic tumors in vitro and its modulation induced by dibutyl cyclic adenosine monophosphate.
Asia Oceania J. Obstet. Gynaecol. 12:285-290(1986)

PubMed=2435620; DOI=10.1016/0090-8258(87)90026-6
Ishiwata I., Ishiwata C., Soma M., Nozawa S., Ishikawa H.
Characterization of newly established human ovarian carcinoma cell line -- special reference of the effects of cis-platinum on cellular proliferation and release of CA125.
Gynecol. Oncol. 26:340-354(1987)

PubMed=3593088; DOI=10.1111/j.1447-0756.1987.tb00014.x
Ishiwata I., Ishiwata C., Nozawa S., Ishikawa H.
Cytological properties of human ovarian carcinoma cell lines.
Asia Oceania J. Obstet. Gynaecol. 13:79-86(1987)

PubMed=2448191; DOI=10.1016/0090-8258(88)90151-5
Ishiwata I., Ishiwata C., Soma M., Ono I., Nakaguchi T., Ishikawa H.
Tumor angiogenic activity of gynecologic tumor cell lines on the chorioallantoic membrane.
Gynecol. Oncol. 29:87-93(1988)

PubMed=9436037
Soma M., Ishiwata I., Ishiwata C., Nakaguchi T., Ono I., Kiguchi K., Hashimoto H., Tachibana T., Ishikawa H., Nozawa S.
Tissue reconstruction of gynecologic tumor cells in the rotation culture system.
Hum. Cell 10:175-181(1997)

PubMed=9573483
Ishiwata I., Tokieda Y., Ishiwata C., Okane N., Iguchi M., Sato K., Ishikawa H.
Effects of feeder cells (human cancer cell lines) on the development of mouse embryos by co-culture.
Hum. Cell 10:237-246(1997)

PubMed=10457904
Ishiwata I., Sudo T., Kiguchi K., Ishikawa H.
Tumor angiogenesis factors produced by cancer cells.
Hum. Cell 12:37-46(1999)

PubMed=11330945; DOI=10.1006/gyno.2001.6132
Watanabe T., Imoto I., Kosugi Y., Ishiwata I., Inoue S., Takayama M., Sato A., Inazawa J.
A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genomic hybridization.
Gynecol. Oncol. 81:172-177(2001)

PubMed=12417041; DOI=10.1111/j.1349-7006.2002.tb01213.x; PMCID=PMC5926887
Watanabe T., Imoto I., Katahira T., Hirasawa A., Ishiwata I., Emi M., Takayama M., Sato A., Inazawa J.
Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers.
Jpn. J. Cancer Res. 93:1114-1122(2002)

PubMed=17671176; DOI=10.1158/0008-5472.CAN-06-4567
Kikuchi R., Tsuda H., Kanai Y., Kasamatsu T., Sengoku K., Hirohashi S., Inazawa J., Imoto I.
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.
Cancer Res. 67:7095-7105(2007)

Cross-references
Cell line collections (Providers) RCB; RCB0692 - Discontinued
Cell line databases/resources CLO; CLO_0051442
CGH-DB; 342-2
CGH-DB; 9351-4
Biological sample resources BioSample; SAMN03472217
Encyclopedic resources Wikidata; Q54896670
Gene expression databases FANTOM5_SSTAR; 10693-109F9
Polymorphism and mutation databases Cosmic; 931366
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number19