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Cellosaurus HTOA (CVCL_5457)

[Text version]
Cell line name HTOA
Accession CVCL_5457
Resource Identification Initiative To cite this cell line use: HTOA (RRID:CVCL_5457)
Comments Population: Japanese.
Doubling time: 74.5 hours (Note=At 5th passage), 68.2 hours (Note=At 25th passage), 72 hours (Note=At 50th passage) (PubMed=2435620); 70 hours (PubMed=3593088).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): RCB=RCB0692

Markers:
AmelogeninX
CSF1PO12,13
D5S81811,13
D7S8209,10
D13S3178,10
D16S5399,13
TH017
TPOX11
vWA17

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Publications

PubMed=2429643; DOI=10.1111/j.1447-0756.1986.tb00192.x
Isamu Ishiwata, Chieko Ishiwata, Shiro Nozawa, Hiroshi Ishikawa;
CA125 production by gynecologic tumors in vitro and its modulation induced by dibutyl cyclic adenosine monophosphate.
Asia Oceania J. Obstet. Gynaecol. 12:285-290(1986)

PubMed=2435620; DOI=10.1016/0090-8258(87)90026-6
Isamu Ishiwata, Chieko Ishiwata, Masayuki Soma, Shiro Nozawa, Hiroshi Ishikawa;
Characterization of newly established human ovarian carcinoma cell line -- special reference of the effects of cis-platinum on cellular proliferation and release of CA125.
Gynecol. Oncol. 26:340-354(1987)

PubMed=3593088; DOI=10.1111/j.1447-0756.1987.tb00014.x
Isamu Ishiwata, Chieko Ishiwata, Shiro Nozawa, Hiroshi Ishikawa;
Cytological properties of human ovarian carcinoma cell lines.
Asia Oceania J. Obstet. Gynaecol. 13:79-86(1987)

PubMed=2448191; DOI=10.1016/0090-8258(88)90151-5
Isamu Ishiwata, Chieko Ishiwata, Masayuki Soma, Isao Ono, Takenori Nakaguchi, Hiroshi Ishikawa;
Tumor angiogenic activity of gynecologic tumor cell lines on the chorioallantoic membrane.
Gynecol. Oncol. 29:87-93(1988)

PubMed=9436037
Masayuki Soma, Isamu Ishiwata, Chieko Ishiwata, Takenori Nakaguchi, Isao Ono, Kazushige Kiguchi, Hisashi Hashimoto, Toshiaki Tachibana, Hiroshi Ishikawa, Shiro Nozawa;
Tissue reconstruction of gynecologic tumor cells in the rotation culture system.
Hum. Cell 10:175-181(1997)

PubMed=9573483
Isamu Ishiwata, Yuko Tokieda, Chieko Ishiwata, Natsumi Okane, Megumi Iguchi, Kahei Sato, Hiroshi Ishikawa;
Effects of feeder cells (human cancer cell lines) on the development of mouse embryos by co-culture.
Hum. Cell 10:237-246(1997)

PubMed=10457904
Isamu Ishiwata, Tadashi Sudo, Kazushige Kiguchi, Hiroshi Ishikawa;
Tumor angiogenesis factors produced by cancer cells.
Hum. Cell 12:37-46(1999)

PubMed=11330945; DOI=10.1006/gyno.2001.6132
Takafumi Watanabe, Issei Imoto, Yoshinori Kosugi, Isamu Ishiwata, Satoshi Inoue, Masaomi Takayama, Akira Sato, Johji Inazawa;
A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genomic hybridization.
Gynecol. Oncol. 81:172-177(2001)

PubMed=12417041; DOI=10.1111/j.1349-7006.2002.tb01213.x; PMCID=PMC5926887
Takafumi Watanabe, Issei Imoto, Tomoyuki Katahira, Akira Hirasawa, Isamu Ishiwata, Mitsuru Emi, Masaomi Takayama, Akira Sato, Johji Inazawa;
Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers.
Jpn. J. Cancer Res. 93:1114-1122(2002)

PubMed=17671176; DOI=10.1158/0008-5472.CAN-06-4567
Ryoko Kikuchi, Hitoshi Tsuda, Yae Kanai, Takahiro Kasamatsu, Kazuo Sengoku, Setsuo Hirohashi, Johji Inazawa, Issei Imoto;
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.
Cancer Res. 67:7095-7105(2007)

Cross-references
Cell line collections (Providers) RCB; RCB0692 - Discontinued
Cell line databases/resources CLO; CLO_0051442
CGH-DB; 342-2
CGH-DB; 9351-4
Biological sample resources BioSample; SAMN03472217
Encyclopedic resources Wikidata; Q54896670
Gene expression databases FANTOM5_SSTAR; 10693-109F9
Polymorphism and mutation databases Cosmic; 931366
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number19