Cellosaurus cell line HOC-7 (CVCL

Cellosaurus HOC-7 (CVCL_5455)

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Cell line name

HOC-7

Synonyms

HOC7

Accession

CVCL_5455

Resource Identification Initiative

To cite this cell line use: HOC-7 (RRID:CVCL_5455)

Comments

Part of: MD Anderson Cell Lines Project.
Part of: OCCP ovarian cancer cell line panel.
Doubling time: 16.4 hours (PubMed=4016745); 26.68 hours (JWGray panel).
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.

Sequence variations

Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Unspecified (PubMed=25230021).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys275Phe (c.824G>T); ClinVar=VCV000376582; Zygosity=Unspecified (PubMed=25230021).

Disease

Ovarian serous adenocarcinoma (NCIt: C7550)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_5454 ! HOC-1

Sex of cell

Female

Age at sampling

Age unspecified

Category

Cancer cell line

STR profile

Source(s): PubMed=25230021

Markers:

Amelogenin	X
CSF1PO	11
D3S1358	15
D5S818	11,12
D7S820	8,9
D8S1179	12,14
D13S317	9,11
D16S539	9
D18S51	14
D21S11	30,31.2
FGA	23,25
Penta D	13
Penta E	7,12
TH01	9.3
TPOX	8,11
vWA	14,16

Web pages

Info; MCLP; -; https://tcpaportal.org/mclp/

Publications

PubMed=4016745
Ronald N. Buick, Rose Pullano, Jeffrey M. Trent;
Comparative properties of five human ovarian adenocarcinoma cell lines.
Cancer Res. 45:3668-3676(1985)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023
Britta Stordal, Kirsten Timms, Angela Farrelly, Danielle Gallagher, Steven Busschots, Mickael Renaud, Julien Thery, Deborah Williams, Jennifer Potter, Thanh Tran, Greg Korpanty ...Show all 19 authors... , Mattia Cremona, Mark S. Carey, Jie Li, Yang Li, Ozlem Aslan, John J. O'Leary, Gordon B. Mills, Bryan T. Hennessy; Show fewer authors
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545
Corine M. Beaufort, Jean C.A. Helmijr, Anna M. Piskorz, Marlous Hoogstraat, Kirsten Ruigrok-Ritstier, Nicolle Besselink, Muhammed Murtaza, Wilfred F.J. van IJcken, Anouk A.J. Heine, Marcel Smid, Marco J. Koudijs ...Show all 14 authors... , James D. Brenton, Els M.J.J. Berns, Jozien Helleman; Show fewer authors
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:e103988.1-e103988.16(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, Agda Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_5455

Encyclopedic resources

Wikidata; Q54890105

Gene expression databases

GEO; GSM1291141

Polymorphism and mutation databases

Cosmic; 923105

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number