Cellosaurus cell line MC4000 (CVCL

Cellosaurus MC4000 (CVCL_5331)

Cross-references
Cell line name	MC4000
Synonyms	MC-4000
Accession	CVCL_5331
Resource Identification Initiative	To cite this cell line use: MC4000 (RRID:CVCL_5331)
Comments	Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a breast carcinoma. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00143. Population: African American. Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease	Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0030 (HeLa)
Sex of cell	Female
Age at sampling	30Y6M
Category	Cancer cell line
Web pages	Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications	PubMed=9150904; DOI=10.1023/A:1005756632293 Richard J. Hambly, John A. Double, Michael J. Thompson, Michael C. Bibby; Establishment and characterisation of new cell lines from human breast tumours initially established as tumour xenografts in NMRI nude mice. Breast Cancer Res. Treat. 43:247-258(1997) PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2 Roderick A.F. MacLeod, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Maren Kaufmann, Herbert Milch, Hans Gunther Drexler; Widespread intraspecies cross-contamination of human tumor cell lines arising at source. Int. J. Cancer 83:555-563(1999) PubMed=20143388; DOI=10.1002/ijc.25242 Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney; Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010)
Biological sample resources	BioSample; SAMN03151743
Encyclopedic resources	Wikidata; Q54904211
Entry history
Entry creation	04-Apr-2012
Last entry update	10-Apr-2025
Version number	23