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Cellosaurus KPL-4 (CVCL_5310)

[Text version]
Cell line name KPL-4
Synonyms KPL4
Accession CVCL_5310
Resource Identification Initiative To cite this cell line use: KPL-4 (RRID:CVCL_5310)
Comments Part of: JFCR45 cancer cell line panel.
Population: Japanese.
Characteristics: ER-negative, PR-negative and ERBB2-positive.
Doubling time: ~30 hours (PubMed=10070858).
Microsatellite instability: Stable (MSS) (PubMed=23671654).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
HLA typing Source: PubMed=25960936
Class I
HLA-AA*26:02,26:02
HLA-BB*15:01,15:01
HLA-CC*03:03,03:03
Class II
HLA-DQDQB1*03:02,03:02
HLA-DRDRB1*11:83,11:83

Source: PubMed=26589293
Class I
HLA-AA*24:17,26:09
HLA-BB*15:01,15:01
HLA-CC*03:03,03:03
Disease Breast inflammatory carcinoma (NCIt: C4001)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,13
D3S135816,17
D5S81811,13
D7S8209,10
D8S117911,16
D13S31712
D16S53912
D18S5115
D21S1129,32.2
FGA19
Penta D10,14
Penta E11,12
TH019
TPOX8
vWA14,19

Run an STR similarity search on this cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=KPL-4
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/breast-cancer-xenograft/kpl-4-xenograft-model/
Publications

PubMed=10070858; DOI=10.1038/sj.bjc.6690114; PMCID=PMC2362677
Junichi Kurebayashi, Takemi Otsuki, C.K. Tang, Masafumi Kurosumi, Shigeru Yamamoto, K. Tanaka, M. Mochizuki, H. Nakamura, Hiroshi Sonoo;
Isolation and characterization of a new human breast cancer cell line, KPL-4, expressing the Erb B family receptors and interleukin-6.
Br. J. Cancer 79:707-717(1999)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Noriyuki Nakatsu, Yoko Yoshida, Kanami Yamazaki, Tomoki Nakamura, Shingo Dan, Yasuhisa Fukui, Takao Yamori;
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=21247443; DOI=10.1186/gb-2011-12-1-r6; PMCID=PMC3091304
Henrik Edgren, Astrid Murumagi, Sara Kangaspeska, Daniel Nicorici, Vesa Hongisto, Kristine Kleivi, Inga H. Rye, Sandra Nyberg, Maija Wolf, Anne-Lise Borresen-Dale, Olli-Pekka Kallioniemi;
Identification of fusion genes in breast cancer by paired-end RNA-sequencing.
Genome Biol. 12:R6.1-R6.13(2011)

DOI=10.4172/2161-0681.1000119
Fredika M. Robertson, Khoi Chu, Sandra V. Fernandez, Zhao-Mei Mu, Xue-Jun Zhang, Hui Liu, Kimberly M. Boley, R. Katherine Alpaugh, Zai-Ming Ye, Moishia C. Wright, Annie Z. Luo ...Show all 17 authors... , Ricardo Oraes, Hong Wu, Matthew Brent Zook, Sanford H. Barsky, Savitri Krishnamurthy, Massimo Cristofanilli; Show fewer authors
Genomic profiling of pre-clinical models of inflammatory breast cancer identifies a signature of epithelial plasticity and suppression of TGFbeta signaling.
J. Clin. Exp. Pathol. 2:119.1-119.11(2012)

PubMed=23671654; DOI=10.1371/journal.pone.0063056; PMCID=PMC3646030
Yu-Heng Lu, T. David Soong, Olivier Elemento;
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:e63056.1-e63056.10(2013)

PubMed=23784380; DOI=10.1007/s10549-013-2600-4; PMCID=PMC4273486
Sandra V. Fernandez, Fredika M. Robertson, Jian-Ming Pei, Lucy Doris Aburto-Chumpitaz, Zhao-Mei Mu, Khoi Chu, R. Katherine Alpaugh, Yong Huang, Yu Cao, Zai-Ming Ye, Kathy Q. Cai ...Show all 16 authors... , Kimberly M. Boley, Andres J.P. Klein-Szanto, Karthik Devarajan, Sankar Addya, Massimo Cristofanilli; Show fewer authors
Inflammatory breast cancer (IBC): clues for targeted therapies.
Breast Cancer Res. Treat. 140:23-33(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=35042871; DOI=10.1038/s41523-021-00379-6; PMCID=PMC8766434
Charlotte Rypens, Francois Bertucci, Pascal Finetti, Fredika M. Robertson, Sandra V. Fernandez, Naoto Tada Ueno, Wendy A. Woodward, Kenneth Van Golen, Peter Vermeulen, Luc Dirix, Patrice Viens ...Show all 15 authors... , Daniel Birnbaum, Gayathri R. Devi, Massimo Cristofanilli, Steven Van Laere; Show fewer authors
Comparative transcriptional analyses of preclinical models and patient samples reveal MYC and RELA driven expression patterns that define the molecular landscape of IBC.
NPJ Breast Cancer 8:12.1-12.12(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5310
Biological sample resources BioSample; SAMN03471036
BioSample; SAMN03473250
Chemistry resources PharmacoDB; KPL4_791_2019
Encyclopedic resources Wikidata; Q54900438
Experimental variables resources EFO; EFO_0006624
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-11134
GEO; GSM590107
GEO; GSM1374604
Polymorphism and mutation databases Progenetix; CVCL_5310
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27